ID A0A0G1F9V1_9BACT Unreviewed; 546 AA.
AC A0A0G1F9V1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=UV59_C0035G0005 {ECO:0000313|EMBL:KKS83623.1};
OS Candidatus Gottesmanbacteria bacterium GW2011_GWA1_43_11.
OC Bacteria; Candidatus Gottesmanbacteria.
OX NCBI_TaxID=1618436 {ECO:0000313|EMBL:KKS83623.1, ECO:0000313|Proteomes:UP000034543};
RN [1] {ECO:0000313|EMBL:KKS83623.1, ECO:0000313|Proteomes:UP000034543}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS83623.1}.
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DR EMBL; LCFB01000035; KKS83623.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1F9V1; -.
DR STRING; 1618436.UV59_C0035G0005; -.
DR PATRIC; fig|1618436.3.peg.1351; -.
DR Proteomes; UP000034543; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KKS83623.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KKS83623.1}.
FT DOMAIN 7..222
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 546 AA; 61945 MW; 8867F4D619564D08 CRC64;
MNFKINESEQ KLRGGYYTPL DLAVFLTKWV RNINPRTVLE PSCGDGVFFE AIDKVNGMKG
VSVLGLEINE NEAQKAQLRA KGTSANIEVQ TEDFLKWSLD NIRNNKSLYD AVVGNPPFIR
YQYLPKEFQQ RSEEIFNELN LPFTKHTNAW VPFVLASLAM LRPGGRLAMV VPAEIIHIIH
AQSLRTYLGK ECKRLVIVDP EELWFKDTLQ GAVLLLAEKR NNTYENAEGV GIYPVKQKEF
LDIDPDIIFS SPKSLNGRTV AGKWTYALLD HSTRNLIDSL IDHPDVYHFN DVADVDVGIV
TGANDYFLVS DETVQEYNLS KWAHPMFGRS EHCPGIIYDE QQHQENKKNG KPTNFIWFSN
KPTDSAIAKK YIHYGEEQGL HLRYKCSVRS PWYSVPSVYA TEIGMLKRSH DIPRLIFNKI
GAFTTDTAYR IRVHNRSSRQ LVGSFLNSLT ALSAELEGRH YGGGVLELVP SEIEKLLIPL
SKKLTVNLAN LDTAIKTLPA RELLAKQDST ILNALGLNLS DQNQLLNNWQ KLHDRRQRTS
SDAETN
//
