ID A0A0G1QA98_9BACT Unreviewed; 785 AA.
AC A0A0G1QA98;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UX23_C0012G0015 {ECO:0000313|EMBL:KKU14623.1};
OS Parcubacteria group bacterium GW2011_GWB1_45_9.
OC Bacteria.
OX NCBI_TaxID=1618879 {ECO:0000313|EMBL:KKU14623.1, ECO:0000313|Proteomes:UP000034512};
RN [1] {ECO:0000313|EMBL:KKU14623.1, ECO:0000313|Proteomes:UP000034512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU14623.1}.
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DR EMBL; LCLK01000012; KKU14623.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1QA98; -.
DR PATRIC; fig|1618879.3.peg.560; -.
DR Proteomes; UP000034512; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 56..228
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 320..569
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 785 AA; 87979 MW; 3E351A570F4327B8 CRC64;
MRRFLVFFFT ISLLGLAGAG AALLFTVRDL PDPSQLGEKQ FVQSTKIYDR TEEILLYEIH
GDEKRTVVPH EEIPEYVRLA TLAIEDQSFY NHPAFDWKGI ARGIWAGISR GRFQGGSTIT
QQLARNSFLT PERTIKRKVR ELILALELER QYSKDEILYL YLNQIPYGGN AYGVEAASQL
YFGKSVRDVN LEEAAILASL VKAPTYYSPW GSHTDELNQR QEYVLAQMFK LDFIDEEEFE
RAKNAEIKFM PQTIGKIRAP HFVVSVQNYL VQKYGEETIE KGGLKVITTL DWKLQELAEK
VVAEGAARNE ELYGGRNAAL LAQDAETGQI LAMVGSRDYF DIQNDGNFNV ATQGLRQPGS
AFKPFVYYAA LQKGYTPDTV IFDVPTEFDT TGNPARSYRP ENFDEKFRGP VTFRQALSQS
LNLPAVKVLY LAGLDNALNV AKDFGISTLT ERGRYGLSLV LGGGEVKLSE LVNAYSVLAR
DGIKHEQTTV LKVEESDGRI LEEYKNNEIQ VADPQIIKQI NDILSDENAR RPLFQNSFSQ
TIVSGHQIAL KTGTTNDYHD AWTIGYTPSL VIGVWAGNNN NQPMHSRGGS ILAAVPIWHT
FISKALKEKE LKTFARPEPV SSQKPVLNGN FAPSGVVHSI LYYVQKNDPT GPPPSNPATD
PQFNNWESAV LAWVQMNAPN ILAFSQQNPP QRQSNLDIEF LTPRNGDWIN ENVFVSVNIQ
SSSPVTKIEL RLNGRLMDSK IGSFSSNIRY DMRLSASVLL TQNELSITAT NAEEVTKEKN
IILYN
//
