ID   A0A0G1R6C9_9BACT        Unreviewed;       485 AA.
AC   A0A0G1R6C9;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
GN   ORFNames=UX37_C0017G0030 {ECO:0000313|EMBL:KKU25638.1};
OS   Microgenomates group bacterium GW2011_GWA2_46_16.
OC   Bacteria.
OX   NCBI_TaxID=1618501 {ECO:0000313|EMBL:KKU25638.1, ECO:0000313|Proteomes:UP000034885};
RN   [1] {ECO:0000313|EMBL:KKU25638.1, ECO:0000313|Proteomes:UP000034885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000256|RuleBase:RU000644}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKU25638.1}.
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DR   EMBL; LCLY01000017; KKU25638.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G1R6C9; -.
DR   PATRIC; fig|1618501.3.peg.517; -.
DR   Proteomes; UP000034885; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01887; IF2_eIF5B; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00487; IF-2; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 2.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000256|RuleBase:RU000644};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU000644}.
FT   DOMAIN          3..173
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
SQ   SEQUENCE   485 AA;  51952 MW;  70974CCBB3D8588A CRC64;
     MTTRPPIVAI LGHVDHGKTT LLDYIRSTHV AELEAGGITQ SIGAYQAEYK GKKLTFIDTP
     GHAAFSKMRS CGTSIADVVV LVVAGDDSVQ PQTIESIKHI KEAKIPFVVA INKMDKADAK
     AEVVKAKLTE HEVFVEGYGG NVPCVEIAGK SGKGVDNLLE TILLLGELEE LPYTPDSPLL
     AMIIEAKIDP QKGVLVSAII KSGRLKLGEM VGTESADAKV RALFGDAGAS LKEATPGMPV
     QILGFRTIPQ VGEVIRPESS DDLSSASLLA GRQGSELGDS LEPLTPIDPL AKRLNLIIKA
     DTAGSLEAIR GSLTTDVNVV TSSTGDVTES DVLMANATGS IILGFNAHVS TSIAKLAEAE
     KVVLKSYKII YELLEYLEKK ILKLMEPTID EEELGKATII KVFEINGDHI AGTLVESGRL
     ETGDTIHLHR QDGMVKDARI KSMRIGKDEV KKVPAGSECG LFLYPNLDVR EKDAIIAYKK
     KLNDI
//