ID A0A0G1REJ0_9BACT Unreviewed; 722 AA.
AC A0A0G1REJ0;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UX77_C0010G0037 {ECO:0000313|EMBL:KKU55546.1};
OS Parcubacteria group bacterium GW2011_GWA1_47_11.
OC Bacteria.
OX NCBI_TaxID=1618792 {ECO:0000313|EMBL:KKU55546.1, ECO:0000313|Proteomes:UP000034505};
RN [1] {ECO:0000313|EMBL:KKU55546.1, ECO:0000313|Proteomes:UP000034505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU55546.1}.
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DR EMBL; LCNL01000010; KKU55546.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1REJ0; -.
DR PATRIC; fig|1618792.3.peg.430; -.
DR Proteomes; UP000034505; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..247
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 338..628
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 722 AA; 79849 MW; 2175CB5012F9969C CRC64;
MKASSNQSFT VTRIKKPRWR SVGMFLVWVI VLGAIAFFSL FIYLAQTLPD PETIAARKIS
ESTKIYDRTG EVLLYDIHGE EKRTIVAWDR ISDNLKKATL AAEDSNFYNH GGFDVRGIAR
SLFKDIASLN LSQGGSTITQ QLVKLALLGS EKTPIRKIKE LVLSIEIERR FSKDQIFWMY
LNQIPYGSNA YGIQAASKTF FDKDASALTI SESAILAALP QAPSRYSPYG NYVPELIGRR
NNILRRMENL GYISEEEYRL ALEEKPVFRK STESITAPHF VLMVKDYLAK KYGEDAIESA
GLKVVTTLDA SLQEMAEASV EKYSAVNAQR YKSSNSSLVS VNPKNGDVLA LVGSKNYFDV
ANQGNYNIAT AQRQPGSAFK PFTYATAFQK GYPDSTILFD ARTEFNPNCS PDSSQLRDQY
GLACYHPRNY DGLFRGPVTL RQALSQSLNV PSVKTLYLAG IGDTMALAKS MGITTLNEPE
RYGLSLVLGG AEVRPIDLVS AYGVFANDGI RNPWRIILKI EDVNGNILEE SSDQPRRVID
EQIARLMNNV LSDNSARAPV FGYNNSLYLP GYDVAAKTGT TQDNRDGWVV GYSPSLATVV
WSGNNNNDPM TAAGAGISAS GPMWNDFMVK ALATLPRDNF PEPNPVNSPK IMLNGNYVYT
APDGTQEIHE ILKYVDRNDP SGPFPENPGR DPLFSNWEWP VSKIYGSAEQ SPSPEPSPSP
TP
//
