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Database: UniProt
Entry: A0A0G1RJL4_9BACT
LinkDB: A0A0G1RJL4_9BACT
Original site: A0A0G1RJL4_9BACT 
ID   A0A0G1RJL4_9BACT        Unreviewed;       297 AA.
AC   A0A0G1RJL4;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE            EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN   ORFNames=UX81_C0038G0003 {ECO:0000313|EMBL:KKU57341.1};
OS   Parcubacteria group bacterium GW2011_GWA2_47_12.
OC   Bacteria.
OX   NCBI_TaxID=1618841 {ECO:0000313|EMBL:KKU57341.1, ECO:0000313|Proteomes:UP000034388};
RN   [1] {ECO:0000313|EMBL:KKU57341.1, ECO:0000313|Proteomes:UP000034388}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKU57341.1}.
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DR   EMBL; LCNP01000038; KKU57341.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G1RJL4; -.
DR   Proteomes; UP000034388; Unassembled WGS sequence.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR   Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR   InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   NCBIfam; TIGR03284; thym_sym; 1.
DR   PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR   PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          14..294
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
SQ   SEQUENCE   297 AA;  34036 MW;  56822F30FCE64A2B CRC64;
     MYTKPYAERK PDTQYRTLLS RIMGEGREVN PIQGEKSKMI IGAQMRFALE NGFPMITERD
     LSGPFMAGAL AEHFAFLHGA RTQEELEQWG CKWWKRWVTP EKCAVFGLSP GDLGPGSYGP
     GWTAMPTPEG KPFNQITEVM RQLKERPYLR THLITPWYPP YVIQHSGLTR KVVVAPCHGW
     LHLLAFPETK ELSVHHFQRS GDMPVGVVFN IIQYAVFAMM AAREIGYTPK ELVYTISDAH
     IYESQFESVC ELLAREARAF PTMELDPTPK TVLDFRIEHF RLSDYHPHPT MKIPTPV
//
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