ID A0A0G1UCB1_9BACT Unreviewed; 895 AA.
AC A0A0G1UCB1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=UY23_C0001G0363 {ECO:0000313|EMBL:KKU91757.1};
OS Candidatus Jorgensenbacteria bacterium GW2011_GWA1_48_11.
OC Bacteria; Candidatus Jorgensenbacteria.
OX NCBI_TaxID=1618660 {ECO:0000313|EMBL:KKU91757.1, ECO:0000313|Proteomes:UP000034956};
RN [1] {ECO:0000313|EMBL:KKU91757.1, ECO:0000313|Proteomes:UP000034956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU91757.1}.
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DR EMBL; LCPF01000001; KKU91757.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1UCB1; -.
DR PATRIC; fig|1618660.3.peg.374; -.
DR Proteomes; UP000034956; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.220.10; Adenine-n6-DNA-methyltransferase Taqi, Chain A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR023135; N6_DNA_MeTrfase_TaqI_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 344..622
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 699..824
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 895 AA; 104384 MW; 88AB59C2381551C6 CRC64;
MKIEDFRSKI ADLIQKYERA KQSGLVKKYS EEETKKDFIL PLFEALGWDV REKREVSAEE
KISGDRVDYG FYIDGHIKFY LEAKPLRADI HKEEYAKQAI KYSWNKGVTW AVLTDFESLI
VFNTQDVKAS LASKLLFEIP YSEYLERFDQ LSLLSRESFK ENSIDDWAEK NGKKFQKVPI
TALLYNDLNE CREMLTKSLV AWNPNLKKDR KLLDEGVQKL LDRLIFLRVA EDRGIEPPTL
IPLLREWHSR KDKNEVPLYA HMVKKFRDLD KTYNSNLFSE HPFEKWEEYG DATEEVIKIL
YGKPGYYEYD FKVMPADILG TVYENYLGYK LSQSKKGIDV HKDAKKRKEQ GIYYTPHFIV
EYIVKNALGP VLDRCETIED LKKVKVLDPA CGSGSFLVQA LELINEKYKR MGAPGNIFTK
TQILLLNIFG VDLDEQAVEI ARLNLLVSAL DGKNPLPKLD QNIKCGNSLI YGTDAELKKY
FGTTFKDQKP FNWEEEFPDV FEKGGFTVVI GNPPWGASID KFNKSFYKDF FVSGKGIIDT
FALFIERSLG LLKEEGYLGF ILPDIVLLKN YPQIRKFILD NCLIKNLYYT GMAFHGVNLD
SVIAILKKEK SEGKRNENYI EIIMDSREKR IKQQLFLNNS DYKFNLYFDD YIIKLKNKVD
SQSIKLGGLL EIHEGIHSGN IRDKLFLDSR LSNKCQKLLF KGVEVERYFE KWGGKFVNYD
KSIINKTAGN YANLGKEEYF LSKKILVRRT GDRIIATIDN DKYFVSNNFF VLYYKKSLKE
EIDLKCILAI LNSKLGTWYF TAIQPRKGKL FAEIKINHLA EIPISKKREF DKIFVLVDQM
SESQKKFHIT KENSNDWERL ESEIEKTDKK IDEEIYKLYR LTPEEIKIVE TTIKD
//
