ID   A0A0G1XHT2_9BACT        Unreviewed;       416 AA.
AC   A0A0G1XHT2;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Vitamin B12-dependent ribonucleotide reductase {ECO:0000313|EMBL:KKW30521.1};
DE   Flags: Fragment;
GN   ORFNames=UY72_C0010G0001 {ECO:0000313|EMBL:KKW30521.1};
OS   Candidatus Uhrbacteria bacterium GW2011_GWD2_52_7.
OC   Bacteria; Candidatus Uhrbacteria.
OX   NCBI_TaxID=1618989 {ECO:0000313|EMBL:KKW30521.1, ECO:0000313|Proteomes:UP000034846};
RN   [1] {ECO:0000313|EMBL:KKW30521.1, ECO:0000313|Proteomes:UP000034846}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKW30521.1}.
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DR   EMBL; LCRD01000010; KKW30521.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G1XHT2; -.
DR   PATRIC; fig|1618989.3.peg.187; -.
DR   Proteomes; UP000034846; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR   GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:InterPro.
DR   Gene3D; 3.20.70.20; -; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR013678; RNR_2_N.
DR   InterPro; IPR000788; RNR_lg_C.
DR   PANTHER; PTHR43371:SF1; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR43371; VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF08471; Ribonuc_red_2_N; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00492}; Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00492}; Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          33..129
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000259|PROSITE:PS51161"
FT   NON_TER         416
FT                   /evidence="ECO:0000313|EMBL:KKW30521.1"
SQ   SEQUENCE   416 AA;  46027 MW;  0C6C8E321B89044C CRC64;
     MSESVTTTSQ ARAADVNTQG AARSVYEFMT SVKEVKKRSG QPEAFVADKL QASVEHALRS
     AGIKEKDLGR YLGRITGQVA SRLQRTFDGH STPTTQDIRD IVTSTIIDNN LVHVARAYLM
     FKSVPVNAAT EKYGTGLTFN RYFTKDGVAP FDMLEWELRS AKITNEKGKI VFEQDGIETP
     KTWSQTAVNV VAQKYFRGKV GTPEREHSMK QLIGRVSKTM ADWGRKDGYF ASANDAQIFE
     DELTWILINQ MAAFNSPVWF NVGVNPHPQC SACFINSVQD DMRSILHLCT TESMLFKQGS
     GTGTNLSNLR SSQEYLGGSN GKSSGPVSFM KGLDAFAGIV KSGGKTRRAA KMVILNADHP
     DIVQFMECKV KEERKAWTLV EAGYDSSMDG EAYGSVFFQN ANNSVRVTDE FMRAVE
//