ID   A0A0G2J7R0_9EURO        Unreviewed;       660 AA.
AC   A0A0G2J7R0;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
GN   ORFNames=EMCG_04215 {ECO:0000313|EMBL:KKZ61166.1};
OS   Emmonsia crescens UAMH 3008.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX   NCBI_TaxID=1247875 {ECO:0000313|EMBL:KKZ61166.1, ECO:0000313|Proteomes:UP000034164};
RN   [1] {ECO:0000313|Proteomes:UP000034164}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 3008 {ECO:0000313|Proteomes:UP000034164};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKZ61166.1}.
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DR   EMBL; LCZI01001338; KKZ61166.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G2J7R0; -.
DR   VEuPathDB; FungiDB:EMCG_04215; -.
DR   Proteomes; UP000034164; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd15761; FYVE1_Vac1p_like; 1.
DR   CDD; cd15737; FYVE2_Vac1p_like; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR006642; Rad18_UBZ4.
DR   InterPro; IPR021565; Rbsn_Rab-bd.
DR   InterPro; IPR036531; Rbsn_Rab-bd_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13510; FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED; 1.
DR   PANTHER; PTHR13510:SF44; RABENOSYN-5; 1.
DR   Pfam; PF01363; FYVE; 2.
DR   Pfam; PF11464; Rbsn; 1.
DR   SMART; SM00064; FYVE; 2.
DR   SMART; SM00734; ZnF_Rad18; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR   SUPFAM; SSF140125; Rabenosyn-5 Rab-binding domain-like; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          341..414
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  74033 MW;  97AAB8EB9330C0DA CRC64;
     MSRRTLGGGR VLGSGRSLNL AAPTSSPQKH SRIHSPSPSS VSLNSQGAAS QISADTQDIV
     SRISLENANS SISRAAAAAG SPRLACPICN EEMLTLLQLN RHLDDTHANL EDDRQVEVKD
     WFQIQVEKAK RFQPLAVLNQ KLKGLDVFEP NHNAAVPVSA PTRTPPGQAG PEPPRIPDPD
     EVVTREHWQP RGLYDVCLEP MCQKRLTVTT GSVNCRKCGK LFCEDHTMYQ MKLSRSAHHE
     PIRGFWCRVC ETCYKSREGY NNHNGQERDH TAEFTELRRQ KVDKAFLEVS RLEKRLTRLT
     QLLSTLPADQ IQSGANKRWS IAWQNDQRKK IEQSVVSWQD DASVPRCPFC QQDFTSYTFR
     RHHCRTCGRV VCGDPITGCS SEIGLDISPK KPTATNEKLS IDIRLCKECK STIFDRRDVA
     QDLLKEPPDL RAYKNLVQFE KGIRLLLPRF QKLLAALQDP ENTPSPTQLT DASKVRRRLM
     DSFAQYDIAA RRIRDLPTQS PTQAKLQKAI YHQATNFLHL HMLPLKSLPK VLKHATPHGN
     KLPHNMNASI TNGGTSALAA IKYGNQESAN STTSLASDNS SAISALETEE KSLRERLIVL
     EEQKFFVTEM IADANRRRKY DEASSLAQNA EDLSKEIDRV NGMIGQLDFE GLYSGQLCVK
//