ID A0A0G2JE50_MOUSE Unreviewed; 804 AA.
AC A0A0G2JE50;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Prominin 1 {ECO:0000313|Ensembl:ENSMUSP00000142632.2};
GN Name=Prom1 {ECO:0000313|Ensembl:ENSMUSP00000142632.2,
GN ECO:0000313|MGI:MGI:1100886};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000142632.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000142632.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142632.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000142632.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142632.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR RefSeq; NP_001157053.1; NM_001163581.1.
DR AlphaFoldDB; A0A0G2JE50; -.
DR SMR; A0A0G2JE50; -.
DR jPOST; A0A0G2JE50; -.
DR ProteomicsDB; 353178; -.
DR Antibodypedia; 1554; 892 antibodies from 42 providers.
DR DNASU; 19126; -.
DR Ensembl; ENSMUST00000197706.5; ENSMUSP00000142632.2; ENSMUSG00000029086.16.
DR GeneID; 19126; -.
DR AGR; MGI:1100886; -.
DR CTD; 8842; -.
DR MGI; MGI:1100886; Prom1.
DR VEuPathDB; HostDB:ENSMUSG00000029086; -.
DR GeneTree; ENSGT00530000063586; -.
DR OrthoDB; 3538424at2759; -.
DR BioGRID-ORCS; 19126; 1 hit in 77 CRISPR screens.
DR ChiTaRS; Prom1; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000029086; Expressed in floor plate of midbrain and 250 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JE50; baseline and differential.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 2.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:A0A0G2JE50,
KW ECO:0007829|PeptideAtlas:A0A0G2JE50};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..804
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002545879"
FT TRANSMEM 94..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 240..284
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 804 AA; 90016 MW; 64C5A05E60EE82A0 CRC64;
MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG IVGPLYKMVH
IFLNVVQPND FPLDLIKKLI QNKNFDISVD SKEIGVLICA ILGLLFIILM PLVGCFFCMC
RCCNKCGGEM HQRQKQNAPC RRKCLGLSLL VICLLMSLGI IYGFVANQQT RTRIKGTQKL
AKSNFRDFQT LLTETPKQID YVVEQYTNTK NKAFSDLDGI GSVLGGRIKD QLKPKVTPVL
EEIKAMATAI KQTKDALQNM SSSLKSLQDA ATQLNTNLSS VRNSIENSLS SSDCTSDPAS
KICDSIRPSL SSLGSSLNSS QGYTTIDEIP NTIQNQTVDV IKDVKNTLDS ISSNIKDMSQ
SIPIEDMLLQ VSHYLNNSNR YLNQELPKLE EYDSYWWLGG LIVCFLLTLI VTFFFLGLLC
GVFGYDKHAT PTRRGCVSNT GGIFLMAGVG FGFLFCWILM ILVVLTFVVG ANVEKLLCEP
YENKKLLQVL DTPYLLKEQW QFYLSGMLFN NPDINMTFEQ VYRDCKRGRG IYAAFQLENV
VNVSDHFNID QISENINTEL ENLNVNIDSI ELLDNTGRKS LEDFAHSGID TIDYSTYLKE
TEKSPTEVNL LTFASTLEAK ANQLPEGKLK QAFLLDVQNI RAIHQHLLPP VQQSLNTLRQ
SVWTLQQTSN KLPEKVKKIL ASLDSVQHFL TNNVSLIVIG ETKKFGKTIL GYFEHYLHWV
FYAITEKMTS CKPMATAMDS AVNGILCGYV ADPLNLFWFG IGKATVLLLP AVIIAIKLAK
YYRRMDSEDV YDDSSVSGMW HFTL
//
