ID A0A0G2JEU2_MOUSE Unreviewed; 470 AA.
AC A0A0G2JEU2;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|ARBA:ARBA00013361};
GN Name=Bmp3 {ECO:0000313|Ensembl:ENSMUSP00000142907.2,
GN ECO:0000313|MGI:MGI:88179};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000142907.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000142907.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142907.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000142907.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142907.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; NP_001297606.1; NM_001310677.2.
DR AlphaFoldDB; A0A0G2JEU2; -.
DR ProteomicsDB; 338497; -.
DR Antibodypedia; 25010; 549 antibodies from 35 providers.
DR DNASU; 110075; -.
DR Ensembl; ENSMUST00000200388.2; ENSMUSP00000142907.2; ENSMUSG00000029335.6.
DR GeneID; 110075; -.
DR AGR; MGI:88179; -.
DR CTD; 651; -.
DR MGI; MGI:88179; Bmp3.
DR VEuPathDB; HostDB:ENSMUSG00000029335; -.
DR GeneTree; ENSGT00940000159775; -.
DR OMA; IETSFCK; -.
DR OrthoDB; 2912454at2759; -.
DR BioGRID-ORCS; 110075; 3 hits in 77 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000029335; Expressed in perichondrium and 129 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JEU2; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0070700; F:BMP receptor binding; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF144; BONE MORPHOGENETIC PROTEIN 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Proteomics identification {ECO:0007829|MaxQB:A0A0G2JEU2,
KW ECO:0007829|ProteomicsDB:A0A0G2JEU2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..470
FT /note="Bone morphogenetic protein 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015039210"
FT DOMAIN 356..470
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 29..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 52967 MW; 83E32ACABEBCBAD3 CRC64;
MAGARGLLCL WLGYFCLNLA QGQRPNLHLP GLRETEPSDR ATGGSPSPDL RPHDKVSEHM
LWLYDRYSGS SRVQATRTPG SQLPGPQPLR GGNTVRSFRA AAAGTPQTKG LHTFNLTSLT
KSENILSATL YFYVGELVNI SLSCPEPQGC SHHTQRQHIQ IDLSAWILKS NQSQLLGHLS
VDVVRPYRDS VSWLSKDITQ LLRKAKQNEE FLIGFNITSR AHELPKRMLF FPEPYILVYA
NDAAISEPES VVSSLQRHRD FTAGTGPRLD SHVREALSVE RRKKRSTGIL LPLQNNELPG
AEYQYKEEGA WEERKPYKSL QTQPPEKSRN KKKQRKGSHQ KGQTLQFDEQ TLKKARRKQW
VEPRNCARRY LKVDFADIGW SEWIISPKSF DAFYCSGACQ FPMPKVAAAA AALHLVLISF
LHGVEEYAKF FETIKSRHHP EHSASGGGRL RDSRALLCAG KDVLTQHLVL
//
