ID A0A0G2JEW4_MOUSE Unreviewed; 182 AA.
AC A0A0G2JEW4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Pre-mRNA-splicing factor 38B {ECO:0000256|RuleBase:RU367025};
GN Name=Prpf38b {ECO:0000313|Ensembl:ENSMUSP00000142929.2,
GN ECO:0000313|MGI:MGI:1914171};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000142929.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000142929.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142929.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000142929.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142929.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be required for pre-mRNA splicing.
CC {ECO:0000256|RuleBase:RU367025}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367025}.
CC -!- SIMILARITY: Belongs to the PRP38 family.
CC {ECO:0000256|ARBA:ARBA00006164, ECO:0000256|RuleBase:RU367025}.
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DR AlphaFoldDB; A0A0G2JEW4; -.
DR jPOST; A0A0G2JEW4; -.
DR ProteomicsDB; 361361; -.
DR Antibodypedia; 53741; 29 antibodies from 15 providers.
DR Ensembl; ENSMUST00000199735.5; ENSMUSP00000142929.2; ENSMUSG00000027881.15.
DR AGR; MGI:1914171; -.
DR MGI; MGI:1914171; Prpf38b.
DR VEuPathDB; HostDB:ENSMUSG00000027881; -.
DR GeneTree; ENSGT01100000263733; -.
DR ChiTaRS; Prpf38b; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000027881; Expressed in embryonic post-anal tail and 261 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JEW4; baseline and differential.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR InterPro; IPR005037; PRP38.
DR PANTHER; PTHR23142:SF2; PRE-MRNA-SPLICING FACTOR 38B; 1.
DR PANTHER; PTHR23142; UNCHARACTERIZED; 1.
DR Pfam; PF03371; PRP38; 1.
PE 1: Evidence at protein level;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU367025};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|RuleBase:RU367025};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367025};
KW Proteomics identification {ECO:0007829|EPD:A0A0G2JEW4,
KW ECO:0007829|MaxQB:A0A0G2JEW4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|RuleBase:RU367025}.
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 182 AA; 20258 MW; 62CDE7BF4EC01901 CRC64;
MANNSPALTG NSQPQHQAAA AVTQQQQQCG GGGGATKPAV SGKQGNVLPL WGNEKTMNLN
PMILTNILSS PYFKVQLYEL KTYHEVVDEI YFKVTHVEPW EKGSRKTAGQ TGMCGGVSRS
SRCWNRRHCF YSILPSIQII YPEVNSKASD GSHNTYRLSI YQSPWIYVYK VYPTPYRPVG
LV
//
