ID A0A0G2JG52_MOUSE Unreviewed; 2065 AA.
AC A0A0G2JG52;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Crystallin beta-gamma domain containing 1 {ECO:0000313|Ensembl:ENSMUSP00000143429.2};
GN Name=Crybg1 {ECO:0000313|Ensembl:ENSMUSP00000143429.2,
GN ECO:0000313|MGI:MGI:109544};
GN Synonyms=Aim1 {ECO:0000313|MGI:MGI:109544};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000143429.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000143429.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000143429.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000143429.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000143429.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006512561.1; XM_006512498.3.
DR AlphaFoldDB; A0A0G2JG52; -.
DR SMR; A0A0G2JG52; -.
DR ProteomicsDB; 373575; -.
DR Antibodypedia; 70882; 26 antibodies from 9 providers.
DR Ensembl; ENSMUST00000200401.2; ENSMUSP00000143429.2; ENSMUSG00000019866.16.
DR AGR; MGI:109544; -.
DR MGI; MGI:109544; Crybg1.
DR VEuPathDB; HostDB:ENSMUSG00000019866; -.
DR eggNOG; ENOG502QUA4; Eukaryota.
DR GeneTree; ENSGT00940000155695; -.
DR InParanoid; A0A0G2JG52; -.
DR OMA; WEAMVLT; -.
DR OrthoDB; 5354696at2759; -.
DR BioGRID-ORCS; 11630; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Crybg1; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; A0A0G2JG52; Protein.
DR Bgee; ENSMUSG00000019866; Expressed in substantia propria of cornea and 133 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JG52; baseline and differential.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0001654; P:eye development; IEA:UniProt.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 6.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR PANTHER; PTHR11818:SF2; BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00030; Crystall; 6.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00458; RICIN; 1.
DR SMART; SM00247; XTALbg; 6.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 9.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0G2JG52,
KW ECO:0007829|MaxQB:A0A0G2JG52};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1408..1461
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1508..1550
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1562..1614
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1615..1657
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1706..1748
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1759..1796
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1797..1840
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1846..1886
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1887..1928
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT REGION 1..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..974
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2065 AA; 223448 MW; 8E803277F74185EF CRC64;
MPLSPPSQGD PREASPSKAP KKHPTFHIWR SKKKQSPSSS CGVFIPHPPG AFGETRAFLV
PDGSQGEPQE LTLHGGELQL SDTPSEVPGP SSTESAMLKK SRAQPPEDTR RKPVLEKLGT
LFTAGRRRNT RNGLESPTNS NSKSASAKVP KTGSEKTKAQ DNQLKATDAG EAGPRQEAEG
QPVESCVQAT PCDAEQSPCS SINVGVVQQC HSNDSAQLEP LQAEGETFPD ATTAAKELLH
SSPGNRSRQE SAETPARSPG EEALPGAGLQ PETARGVSGS PPEEHLVGGV GEAPDGAPGV
GAEAGSLGAP GDAVPPGEPP AQDAETSRTA GSVDRAHPTK VLTLDIYLSK TEVAQVDEPA
SIAPGTDDCE DSDDMEKRSS GRRSGRRRKS QKSTDSPGAD AVAPESAAKD EAVFDDEVAP
DAAAENCLAE RKVKSVQAVP DGGAAPVACP EPKASSCPRG QPRGEPDRSK PLSPTKRKGR
SRVPEAVPSS PGSGSRAPAK ESPPKRAPAA ADSGEEAGRV VPRELTVKSS SLLPEIKPEH
KRGPLPHHFD SRGDGGRSRG TGASDADGLK PRNQFGVGRS TVTTKVTLPA RPKHVELNLK
TPKNPDSLGN EHNSFSQPVH KGNTANKISL FENKRANSSP RHPDVRNTRN NPPSSKTFVG
RAKLNLAKKA KEMEQPEKKA VSTSHQNGLV VKEPSAEGKG TAVPVPREEI RPATRGGEGE
STKDQVLRPE PEQSDKLDVQ TDTAYPSHPG PTALVPVKDS ELSGEGQPEA ADSKGPVLNN
TSDVAQDIAA ICDAREAPPK PQDAFSDSQP ASAAESARES SLPPSAPISV DAPQDGCVQV
PICSVPCTAL EVSENHNGCV SPVSPHTEKT PISKPGVGEA SPPSTPEHSP ETMGKDCPSK
VLVQVRSFVL PVENPQDVSS QVISESSEVR EAQLPSCHSN EPEVVSVTTC VPQHEDAPDT
SPKDIHHREG HVAQSRPHIT QSGPEKAPPI QSSSGMPQTA EFILTHSPSS RSHAEGPQRP
GQDATSPLTP TRLLNISAGS DNSVLDSSSD MEKFTEIIKK MDSAVCVPQK KKKARVPNSP
APHFAMPPIH EDSLEKVFDP NVFTIGLGKK KESLAEVSPA LHLLQNHDPI SKLRAKRAST
EQSIVFKSLH TNSNGKSEPQ TTSEASDKEN RDINSGGVKR SRLENSTLFS SMLSSLPQDK
VFSPSVTSVN TMSTSFSTSQ NSSVSQSSVV QPRKEGGLPC GSDKEQPHLA PHNSLKVFNF
NSSNTSRLGS SHMEKYPQKE GSKEDVNSQG NLQLPENNLS DLPKLKNSDG VEGILKSNLP
NVGSVDADFL GLFKASRYDP GHSFSGMSLS DSMTLRGSMH SKLNPRPGKV VIFSEPDVSE
ECIEVFGDIQ DCSSWRLSPV IVVKVVRGCW ILYEKANFEG HSLALEEGEL ELSSIWGTEE
MLDEEAESDK PVVIGSIRHV VQDYRISQID LFTEPEGLGL LNSYFDDTEE MQGFPVMQKT
CSIKVHWGTW LIYEEPGFQG VPFILEPGEY PDLSFWDTEE AYIGSMRPLK MGGRKVEFPT
DPKVVIYEKP SFEGRCMELE TEMSSFIMEG GETEETTGNN NLPFTSVGSM KVLRGVWVAY
EKCGFTGHQY LLEEGEYRDW NAWGGYNGEL QSLRPILSDF SNAHMIMYSE KNFGSKGSSI
DVLGIVANLK ETGYGVKTQS INVLSGVWVA YENPDFTGEQ YVLDKGFYTS FEDWGGKNCK
ISSVQPICLD SFTGPRRRNQ IHLFSEPQFQ GQSQSFEETI DQIDDSFQTK SCRVLGGSWV
AYDGENFSGN QYVLEEGHYP CLSAMGCLPG ATLKSLRFID FEFSEPTIIL FERENFKGKK
IELNAETVNL RSLGFNTQIR SVRVVGGIWV TYEYGNYRGR QFLLSPAEVP NWYEFSACRQ
IGSLRPFAQK RIYFRLRNKA TGLFMSTNGN LEDLKLLRVQ VMEDVGADDQ IWIYQEGCIK
CRIAEDCCLT IVGSLVTSGS KLGLALDQNV DSQFWCMKSD GRIYSKMKPN LVLDVKGGAQ
YDQNHIILNT VSTEKLTQVW EAMVL
//
