ID A0A0G2JM09_HUMAN Unreviewed; 410 AA.
AC A0A0G2JM09;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Killer cell immunoglobulin-like receptor {ECO:0000313|EMBL:QBF54157.1, ECO:0000313|EMBL:QKY12238.1, ECO:0000313|Ensembl:ENSP00000478344.1};
GN Name=KIR3DL3 {ECO:0000313|EMBL:QBF54157.1,
GN ECO:0000313|Ensembl:ENSP00000478344.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000478344.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000478344.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|EMBL:QFG75910.1}
RP NUCLEOTIDE SEQUENCE.
RA Loh L., Nemat-Gorgani N., Norman P.J.;
RT "KIR alleles.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QBF54157.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30745901;
RA Leaton L.A., Shortt J., Kichula K.M., Tao S., Nemat-Gorgani N.,
RA Mentzer A.J., Oppenheimer S.J., Deng Z., Hollenbach J.A., Gignoux C.R.,
RA Guethlein L.A., Parham P., Carrington M., Norman P.J.;
RT "Conservation, Extensive Heterozygosity, and Convergence of Signaling
RT Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.";
RL Front. Immunol. 10:24-24(2019).
RN [4] {ECO:0000313|EMBL:QKY12238.1}
RP NUCLEOTIDE SEQUENCE.
RA Roe D., Vierra-Green C., Spellman S., Maiers M., Kuang R.;
RT "A Detailed View of KIR Haplotype Structures and Gene Families as Provided
RT by a New Motif-based Multiple Sequence Alignment.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSP00000478344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; GU182345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GU182349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GU182355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; MK034720; QBF54157.1; -; Genomic_DNA.
DR EMBL; MK034732; QBF54169.1; -; Genomic_DNA.
DR EMBL; MK034735; QBF54172.1; -; Genomic_DNA.
DR EMBL; MH938297; QFG75910.1; -; Genomic_DNA.
DR EMBL; MN167510; QKY12238.1; -; Genomic_DNA.
DR EMBL; MN167515; QKY12276.1; -; Genomic_DNA.
DR EMBL; MN167521; QKY12334.1; -; Genomic_DNA.
DR EMBL; MN167526; QKY12376.1; -; Genomic_DNA.
DR EMBL; MN167527; QKY12385.1; -; Genomic_DNA.
DR EMBL; MN167529; QKY12401.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G2JM09; -.
DR SMR; A0A0G2JM09; -.
DR MassIVE; A0A0G2JM09; -.
DR Ensembl; ENST00000613313.1; ENSP00000483190.1; ENSG00000278490.1.
DR Ensembl; ENST00000614181.1; ENSP00000482181.1; ENSG00000274724.1.
DR Ensembl; ENST00000617919.1; ENSP00000478344.1; ENSG00000276086.1.
DR HGNC; HGNC:16312; KIR3DL3.
DR Proteomes; UP000005640; Unplaced.
DR CDD; cd05711; IgC2_D2_LILR_KIR_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF113; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL3; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 3.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Receptor {ECO:0000313|EMBL:QBF54157.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..410
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014024423"
FT DOMAIN 34..118
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 40..102
FT /note="Immunoglobulin subtype 2"
FT /evidence="ECO:0000259|SMART:SM00408"
FT DOMAIN 129..218
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 229..316
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
SQ SEQUENCE 410 AA; 44926 MW; 57A5B66B9EFFFBF0 CRC64;
MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR SRLGFNEFSL
SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP HSPTGWSAPS NPVVIMVTGV
HRKPSLLAHP GPLVKSGETV ILQCWSDVRF ERFLLHREGI TEDPLRLVGQ LHDAGSQVNY
SMGPMTPALA GTYRCFGSVT HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV
TLSCSSRSLF DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL
PHAWSDPSDP LPVSVTGNSR YLHALIGTSV VIIPFAILLF FLLHRWCANK KNAVVMDQEP
AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR PKTPPTDTSV
//
