ID A0A0G2JQI0_HUMAN Unreviewed; 148 AA.
AC A0A0G2JQI0;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
DE Flags: Fragment;
GN Name=TUBGCP5 {ECO:0000313|Ensembl:ENSP00000485856.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000485856.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000485856.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000485856.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC at the centrosome. {ECO:0000256|RuleBase:RU363050}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
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DR EMBL; AC135069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; A0A0G2JQI0; -.
DR PeptideAtlas; A0A0G2JQI0; -.
DR Ensembl; ENST00000630135.2; ENSP00000485856.1; ENSG00000276856.3.
DR HGNC; HGNC:18600; TUBGCP5.
DR ChiTaRS; TUBGCP5; human.
DR Proteomes; UP000005640; Unplaced.
DR Bgee; ENSG00000276856; Expressed in pancreas and 6 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF33; GAMMA-TUBULIN COMPLEX COMPONENT 5; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|RuleBase:RU363050};
KW Proteomics identification {ECO:0007829|EPD:A0A0G2JQI0,
KW ECO:0007829|MaxQB:A0A0G2JQI0};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 2..115
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000485856.1"
SQ SEQUENCE 148 AA; 17076 MW; A11BE92D8FC1D3A8 CRC64;
XRVKLMHFVN SLHNYIMTRI LHSTGLEFQH QVEEAKDLDQ LIKIHYRYLS TIHDRCLLRE
KVSFVKEAIM KVLNLALMFA DGWQAGLGTW RMESIEKMES DFKNCHMFLV TILNKAVCRG
SFPHFSIGLP VVCIRRWSLL STGGLGGT
//
