GenomeNet

Database: UniProt
Entry: A0A0G2JWP2_RAT
LinkDB: A0A0G2JWP2_RAT
Original site: A0A0G2JWP2_RAT 
ID   A0A0G2JWP2_RAT          Unreviewed;      1713 AA.
AC   A0A0G2JWP2;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   30-AUG-2017, entry version 16.
DE   SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|Ensembl:ENSRNOP00000069957};
GN   Name=Nalcn {ECO:0000313|Ensembl:ENSRNOP00000069957,
GN   ECO:0000313|RGD:628710};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000069957, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000069957, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069957,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000069957}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069957};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000069957}.
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DR   EMBL; AABR07019583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSRNOT00000089695; ENSRNOP00000069957; ENSRNOG00000004752.
DR   RGD; 628710; Nalcn.
DR   GeneTree; ENSGT00830000128247; -.
DR   Reactome; R-RNO-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000004752; -.
DR   ExpressionAtlas; A0A0G2JWP2; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF252; PTHR10037:SF252; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     41     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     67     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    299    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    881    905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    956    974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1017   1040       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1134   1157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1216   1239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1259   1287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1299   1327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1398   1422       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      384    603       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      887   1162       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1224   1432       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      798    827       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1713 AA;  197613 MW;  EB5E14E51E1401C3 CRC64;
     MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT
     FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV
     SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS
     VSIFLLFFLL LYGILGVQMF GTFTYHCVVN DTKPGNVTWN SLAIPDTHCS PELEEGYQCP
     PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEASSQE GWVFLMYRAI DSFPRWRSYF
     YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGTRS STTSTATTQM FHEDAAGGWQ
     LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVTVDVIV AASNYYKGEN FRRQYDEFYL
     AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHVYPDLY HSQFTYFQVL
     RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF
     PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPLVAIYFI LYHLFATLIL LSLFVAVILD
     NLELDEDLKK LKQLKQSEAN ADTKEKLPLR LRIFEKFPNR PQMVKISKLP SDFTVPKIRE
     SFMKQFIDRQ QQDTCCLFRI LPSTSSSSCD NPKRPTVEDN KYIDQKLRKS VFSIRARNLL
     EKETAVTKIL RACTRQRMLS GSFEGQPAKE RSILSVQHHI RQERRSLRHG SNSQRISRGK
     SLETLTQDHS NTVRYRNAQR EDSEIKMIQE KKEQAEMKRK VQEEELRENH PYFDKPLFIV
     GREHRFRNFC RVVVRARFNA SKTDPVTGAV KNTKYHQLYD LLGLVTYLDW VMITVTICSC
     ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI RDFGGVMDIF
     IYLVSLIFLC WMPQNVPAES GAQLLMVLRC LRPLRIFKLV PQMRKVVREL FSGFKEIFLV
     SILLLTLMLV FASFGVQLFA GKLAKCNDPN IIRREDCNGI FRINVSVSKN LNLKLRPGEK
     KPGFWVPRVW ANPRNFNFDN VGNAMLALFE VLSLKGWVEV RDVIIHRVGP IHGIYIHVFV
     FLGCMIGLTL FVGVVIANFN ENKGTALLTV DQRRWEDLKS RLKIAQPLHL PPRPDNDGFR
     AKMYDITQHP FFKRTIALLV LAQSVLLSVK VTMKIIAMSP AGFWQSRRNR YDLLVTSLGV
     VWVVLHFALL NAYTYMMGAC VIVFRFFSIC GKHVTLKMLL LTVVVSMYKS FFIIVGMFLL
     LLCYAFAGVV LFGTVKYGEN INRHANFSSA GKAITVLFRI VTGEDWNKIM HDCMVQPPFC
     TPDEFTYWAT DCGNYAGALM YFCSFYVIIA YIMLNLLVAI IVENFSLFYS TEEDQLLSYN
     DLRHFQIIWN MVDDKREGVI PTFRVKFLLR LLRGRLEVDL DKDKLLFKHM CYEMERLHNG
     GDVTFHDVLS MLSYRSVDIR KSLQLEELLA REQLEYTIEE EVAKQTIRMW LKKCLKRIRA
     KQQQSCSIIH SLRESQQQEL SRFLNPPSIE TTQPSEDTNA NSQDHNTQPE SSSQQQLLSP
     TLSDRGGSRQ DAADTGKPQR KIGQWRLPSA PKPISHSVSS VNLRFGGRTT MKSVVCKMNP
     MPDTASCGSE VKKWWTRQLT VESDESGDDL LDI
//
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