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Database: UniProt
Entry: A0A0G2JZE1_RAT
LinkDB: A0A0G2JZE1_RAT
Original site: A0A0G2JZE1_RAT 
ID   A0A0G2JZE1_RAT          Unreviewed;       336 AA.
AC   A0A0G2JZE1;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=TNF receptor superfamily member 10b {ECO:0000313|Ensembl:ENSRNOP00000071012.2};
GN   Name=Tnfrsf10b {ECO:0000313|Ensembl:ENSRNOP00000071012.2,
GN   ECO:0000313|RGD:1308041};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071012.2, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000071012.2, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071012.2,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000071012.2}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071012.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   AlphaFoldDB; A0A0G2JZE1; -.
DR   STRING; 10116.ENSRNOP00000071012; -.
DR   Ensembl; ENSRNOT00000077758.2; ENSRNOP00000071012.2; ENSRNOG00000038483.6.
DR   AGR; RGD:1308041; -.
DR   AGR; RGD:15004308; -.
DR   RGD; 1308041; Tnfrsf10b.
DR   VEuPathDB; HostDB:ENSRNOG00000038483; -.
DR   GeneTree; ENSGT00940000162427; -.
DR   InParanoid; A0A0G2JZE1; -.
DR   OMA; CAKCKPG; -.
DR   Reactome; R-RNO-202733; Cell surface interactions at the vascular wall.
DR   Reactome; R-RNO-3371378; Regulation by c-FLIP.
DR   Reactome; R-RNO-5218900; CASP8 activity is inhibited.
DR   Reactome; R-RNO-69416; Dimerization of procaspase-8.
DR   Reactome; R-RNO-75158; TRAIL signaling.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000038483; Expressed in jejunum and 18 other cell types or tissues.
DR   ExpressionAtlas; A0A0G2JZE1; baseline and differential.
DR   GO; GO:0009986; C:cell surface; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0045121; C:membrane raft; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0002020; F:protease binding; ISO:RGD.
DR   GO; GO:0045569; F:TRAIL binding; IEA:InterPro.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:RGD.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IMP:RGD.
DR   GO; GO:0008584; P:male gonad development; IEP:RGD.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0010033; P:response to organic substance; IEP:RGD.
DR   GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; ISO:RGD.
DR   CDD; cd08315; Death_TRAILR_DR4_DR5; 1.
DR   CDD; cd10580; TNFRSF10; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR020465; TNFR_10.
DR   InterPro; IPR034024; TNFRSF10_N.
DR   InterPro; IPR034029; TNFRSF10A/B_death.
DR   PANTHER; PTHR46330; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; 1.
DR   PANTHER; PTHR46330:SF6; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01956; TNFACTORR10.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00208; TNFR; 2.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF57586; TNF receptor-like; 2.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..336
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035279488"
FT   TRANSMEM        144..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          51..92
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          51..92
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   DOMAIN          93..132
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          93..132
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          254..323
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   DISULFID        71..84
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        74..92
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        111..124
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        114..132
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   336 AA;  37225 MW;  35DEE38C93545DB7 CRC64;
     MLQAFLLLSF FVPVTAKLAQ DRPADLQRLK QSPLECPAGQ YLSKEDGSCK ACIDGENYTS
     GPNVLPSCLS CRVCKEDKVI KSRCVKARNT ECECKPGSFE DKDSTEICQT CSNCTDGEDE
     VIPCTPKANR KCVPKNTQIP QHNLGLIIGL LASVISVVLF VAVIWKTKAW ESVCLFMTRV
     YPGCEQDHEN TVGLSLLDAQ TSRKTNGSHH NTEPDRTQSS PLGRKLLVLA NGNNPADALK
     LIFERCSTEV PFNSWDRLMR HMGLTDNQIQ MVRAETQVPC EVLYQMLLKW LYQTGLGASI
     NHLLGALEAV GERCALEEIE DYAVKSGKFV YQNTTA
//
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