GenomeNet

Database: UniProt
Entry: A0A0G2K149_RAT
LinkDB: A0A0G2K149_RAT
Original site: A0A0G2K149_RAT 
ID   A0A0G2K149_RAT          Unreviewed;       973 AA.
AC   A0A0G2K149;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   22-NOV-2017, entry version 22.
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 5 {ECO:0000313|Ensembl:ENSRNOP00000071700};
GN   Name=Trpc5 {ECO:0000313|Ensembl:ENSRNOP00000071700,
GN   ECO:0000313|RGD:619787};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071700, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000071700, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071700,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000071700}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071700};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000071700}.
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DR   EMBL; AABR07040953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07040954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07040955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07040956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07040957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07040958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07040959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_017457389.1; XM_017601900.1.
DR   UniGene; Rn.212751; -.
DR   Ensembl; ENSRNOT00000091423; ENSRNOP00000071700; ENSRNOG00000027233.
DR   GeneID; 140933; -.
DR   CTD; 7224; -.
DR   RGD; 619787; Trpc5.
DR   GeneTree; ENSGT00760000119180; -.
DR   OMA; GFNEYVH; -.
DR   Reactome; R-RNO-3295583; TRP channels.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000027233; -.
DR   ExpressionAtlas; A0A0G2K149; baseline and differential.
DR   GO; GO:0034704; C:calcium channel complex; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0030426; C:growth cone; IDA:RGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0045121; C:membrane raft; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0003779; F:actin binding; IDA:RGD.
DR   GO; GO:0042805; F:actinin binding; IDA:RGD.
DR   GO; GO:0051117; F:ATPase binding; IPI:RGD.
DR   GO; GO:0005262; F:calcium channel activity; ISO:RGD.
DR   GO; GO:0030276; F:clathrin binding; IDA:RGD.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; ISO:RGD.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0050774; P:negative regulation of dendrite morphogenesis; IMP:RGD.
DR   GO; GO:0030182; P:neuron differentiation; IEP:RGD.
DR   GO; GO:0045773; P:positive regulation of axon extension; IMP:RGD.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:RGD.
DR   GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IMP:RGD.
DR   GO; GO:1902630; P:regulation of membrane hyperpolarization; IMP:RGD.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005461; TRPC5_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF24; PTHR10117:SF24; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01646; TRPCHANNEL5.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    326    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    362    381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    401    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    439    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    479    498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    598    620       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       38    117       ANK_REP_REGION. {ECO:0000259|Pfam:
FT                                PF12796}.
FT   DOMAIN      175    237       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      375    634       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   973 AA;  111302 MW;  CBD0D8FF30C1564E CRC64;
     MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ ALQSRDLLQC
     QHHCMDPLGR SALLIAIENE NLEIMELLLN HSVYVGDALL YAIRKEVVGA VELLLSYRKP
     SGEKQVPTLM MDTQFSEFTP DITPIMLAAH TNNYEIIKLL VQKRVTIPRP HQIRCNCVEC
     VSSSEVDSLR HSRSRLNIYK ALASPSLIAL SSEDPILTAF RLGWELKELS KVENEFKAEY
     EELSQQCKLF AKDLLDQARS SRELEIILNH RDDHSEELDP QKYHDLAKLK VAIKYHQKEF
     VAQPNCQQLL ATLWYDGFPG WRRKHWVVKL LTCMTIGFLF PMLSIAYLIS PRSNLGLFIK
     KPFIKFICHT ASYLTFLFML LLASQHIVRT DLHVQGPPPT VVEWMILPWV LGFIWGEIKE
     MWDGGFTEYI HDWWNLMDFA MNSLYLATIS LKIVAYVKYN GSRPREEWEM WHPTLIAEAL
     FAISNILSSL RLISLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY
     YETRAIDEPN NCKGIRCEKQ NNAFSTLFET LQSLFWSVFG LLNLYVTNVK ARHEFTEFVG
     ATMFGTYNVI SLVVLLNMLI AMMNNSYQLI ADHADIEWKF ARTKLWMSYF DEGGTLPPPF
     NIIPSPKSFL YLGNWFNNTF CPKRDPDGRR RRHNLRSFTE RHADSLIQNQ HYQEVIRNLV
     KRYVAAMIRN SKTNEGLTEE NFKELKQDIS SFRYEVLDLL GNRKHPRRSF STSSAEFSQR
     DDTNDGSGGA RAKSKSVSFN LGCKKKACQG APLIRTMPRA SGAQGKPKAE SSGKRSFMGP
     SFKKLGLLFS KFNGQTSEPT SEPMYTISDG IAQQHSMWQD IRYSQMEKGK AEACSQSEMN
     LSEVELGEIR GAARSSECPL ACSSSLHCAS GICSSNSKLL DSSEDVFETW GEACDLLMHK
     WGDGQEEQVT TRL
//
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