ID A0A0G2K665_RAT Unreviewed; 1387 AA.
AC A0A0G2K665;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=GTPase activating protein testicular GAP1 {ECO:0000313|Ensembl:ENSRNOP00000073694.1};
GN Name=Tgap1 {ECO:0000313|Ensembl:ENSRNOP00000073694.1,
GN ECO:0000313|RGD:1359558}; Synonyms=tGap1 {ECO:0000313|RGD:1359558};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000073694.1, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000073694.1, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073694.1,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000073694.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073694.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006232196.1; XM_006232134.3.
DR RefSeq; XP_017446217.1; XM_017590728.1.
DR AlphaFoldDB; A0A0G2K665; -.
DR SMR; A0A0G2K665; -.
DR STRING; 10116.ENSRNOP00000073694; -.
DR Ensembl; ENSRNOT00000082912.2; ENSRNOP00000073694.1; ENSRNOG00000022511.8.
DR AGR; RGD:1359558; -.
DR RGD; 1359558; Tgap1.
DR eggNOG; KOG4724; Eukaryota.
DR GeneTree; ENSGT00940000163685; -.
DR InParanoid; A0A0G2K665; -.
DR OrthoDB; 2964977at2759; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000022511; Expressed in testis and 11 other cell types or tissues.
DR ExpressionAtlas; A0A0G2K665; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 4.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179:SF39; GENE 1527-RELATED; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 4.
DR SMART; SM00324; RhoGAP; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 4.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50238; RHOGAP; 4.
PE 1: Evidence at protein level;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 291..476
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 578..761
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 854..1037
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1129..1312
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 499..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1387 AA; 157602 MW; 893520FD5418FDC6 CRC64;
MDMTEEEDVG EENRTVVCQG AVVIRRGWMR KKRYLTLFND VLVISSKLNK KKFKIKHVIP
LTYLWVGDEV DAFRSDNTAA SKSIYLYWPM GHVVATFRSM EQTIWWYFFL QRSIREAKKH
NKIEIPMQIF TEDIACCDTP LYVTATNFDT VNDIISKLLP MIRKHNTEDY QLWFCPGPGK
APRLLQGHEY PHDIRMINIQ KNFSSRDLRN FTAVPSLPGV IMKYLNADVH GKFILKPRNS
TRSQQQKNMK EKTFKKQRTS ITSWLDRGSV PHQDKVCTIP QVKKGGKLFG RELSSICQDG
DLPSAILDML YLLKKEGPTT KGVFIEPPST TLFQTVKDKL DSGEEVDIEK QSVHVVAWIF
KDFLQNIEGS LMTSKLYDEW IAVTEKVNDE EKLVAVQSLL DKMPPENAAL LRQLFRILYE
IKNNSAVNEM SSYHLSVGLA PCLLFVPSSC NNGMTNDISK KISLVKFMIE NSPQFFGEDL
AAVWHGASLY HRPGAKSLCP QSTPTNSGNV KETKHGLSSS PSGRTCTPGY NTLRRRSAAL
LPHEGIIDSQ KHEVNVYTKP TVPSLNPPQA KQKCLFGKSL TSLFEDKKLP TPILDMLSII
AEKGHESDHI FKILPKESHW SLRYRLDSEQ HIDWDEECVL VIASVLKDFI INIDGSLLTL
EFYENWLSIP DEGTLAEKIN AIQSLLQQIP EPNFILLKHL VYVLVIIKDS SMNNLDSYRL
SLRIAPHVLW GKTSRDSLFG TDVLRKLSIM QIMIDNYHEI FGNDDMFIKH TDKESNDLRM
NEESKSSSDK SPVMTNVIAC CTGTTCDNNE KLNISCAALQ EEGPPEKCED NEYSNPPVRC
LFPLRPAKKC LFGQPLTSIF EDKKIPTPIF DMLSIIAEKG KDTDHIFKTL SEYSHWSLRD
KIDTYQYINW NEERVLVIAS VLKDFITHID GSLLTCELYE SWLSVPDEGT LAEQINAIQR
LLQKIPEPNF ILLKHLICVL VIIKDSSTNK LDTNRLSLRL GPHLLWGWTS SDAFFGKNVS
RKLSIIQIMI DNYHQIFGND DMFIKHTDKE SDDLKMNEES KSSSDKSPVM TNVIACCTGT
TCDKNEKFNI SYAALQVAGP TEKQKSNIYT KPPEYSNPTP SRKKCLFGKN LTSIYVDSKL
PAPILEMLSI IAEKGKESDQ IFAILPENSH WSLRERIESE ELIDWNEEGI LVIASVLKDF
ITNIEGSLLT SDLYESWLSV PDEGTLAGKI NAIQRLLLKI PQANFILLKH LICVLVKIRD
SSMNNLDSNN LSVRIAPYVL WNQTPKDTLF GSDVSRKMSI IQIMIDNYSQ IFGNDSIFCK
GIDKRPEDLK TCPDSINASG KSPIMNEFLG GRNRKTYDNS ENFKISSIAL QEEGPTGQDT
KTATYKW
//
