GenomeNet

Database: UniProt
Entry: A0A0G2K997_RAT
LinkDB: A0A0G2K997_RAT
Original site: A0A0G2K997_RAT 
ID   A0A0G2K997_RAT          Unreviewed;       669 AA.
AC   A0A0G2K997;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   SubName: Full=Two pore calcium channel protein 1 {ECO:0000313|Ensembl:ENSRNOP00000074914};
GN   Name=Tpcn1 {ECO:0000313|Ensembl:ENSRNOP00000074914,
GN   ECO:0000313|RGD:708494};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000074914, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000074914, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074914,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000074914}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074914};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000074914}.
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DR   EMBL; AABR07036390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSRNOT00000079639; ENSRNOP00000074914; ENSRNOG00000059344.
DR   RGD; 708494; Tpcn1.
DR   GeneTree; ENSGT00530000063660; -.
DR   OMA; WLGFHTF; -.
DR   Reactome; R-RNO-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000059344; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF231; PTHR10037:SF231; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2K997};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     30     48       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     85    107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    114    133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    153    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    298    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    330    348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    360    378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    420    439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    545       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        8    183       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      294    543       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   669 AA;  78492 MW;  4C431B353C491E15 CRC64;
     ELSHLMVVVF ECMKLRWLGF HTFVRHKRTM VKTLFLVVQF IEAIVVLVRQ VHVRVTGIRC
     IFLDCRYLEM VTFIMRQIFQ SLPPFMDILL LLLFFMIIFA ILGFYLFSTN PSDPYFNTLE
     NSIVNLFVLL TTANFPDVMM PSYSRNPWSC VFFIVYLSIE LYFIMNLLLA VVFDTFNDIE
     KHKFKSLLLH KRTAIQHAYH LLVSQRRPAG ISYRQFEGLM RFYKPRMSAR ERFLTFKALN
     QSNTPLLSLK DFYDIYEVAA LQWKAKKNRQ HWFDELPRTA FLIFKGINIL VNSKAFQYFM
     YLVVAVNGVW ILVETFMLKG GNFISKHVPW SYLVFLTIYG VELFMKVAGL GPVEYLSSGW
     NLFDFSVTAF AFLGLLALTL NMEPFYFIVV LRPLQLLRLF KLKKRYRNVL DTMFELLPRM
     ASLGLTLLTF YYSFAIVGME FFSGRLSPNC CNSSTVADAY RFINHTVGNK TKVEEGYYYL
     NNFDNILNSF VTLFELTVVN NWYIIMEGVT SQTSHWSRLY FMTFYIVTMV VMTIIVAFIL
     EAFVFRMNYS RKSQESEVDS GIVIEKEMSK EELLAILELH REARGTSSDI TRLLDTLSQM
     EKYQQNSMVF LGRRSRTKSD LSLKMYQEEI QEWYEEHARE QEQQQLRGSA PSPAAQQTPG
     SRQRSQTVT
//
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