ID A0A0G2K9T4_RAT Unreviewed; 7382 AA.
AC A0A0G2K9T4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Microtubule-actin crosslinking factor 1 {ECO:0000313|Ensembl:ENSRNOP00000075119.2};
GN Name=Macf1 {ECO:0000313|Ensembl:ENSRNOP00000075119.2,
GN ECO:0000313|RGD:1306057};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000075119.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000075119.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075119.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:16641100}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.;
RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT regulation of aquaporin-2 phosphorylation at two sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN [3] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000075119.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075119.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the plakin or cytolinker family.
CC {ECO:0000256|ARBA:ARBA00009109}.
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DR jPOST; A0A0G2K9T4; -.
DR Ensembl; ENSRNOT00000081482.2; ENSRNOP00000075119.2; ENSRNOG00000016047.8.
DR RGD; 1306057; Macf1.
DR VEuPathDB; HostDB:ENSRNOG00000016047; -.
DR GeneTree; ENSGT00940000155824; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000016047; Expressed in lung and 19 other cell types or tissues.
DR ExpressionAtlas; A0A0G2K9T4; baseline and differential.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21240; CH_MACF1_rpt2; 1.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 14.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 33.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 5.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF21; EPIPLAKIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00681; Plectin; 10.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 17.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM01129; DELLA; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 19.
DR SMART; SM00150; SPEC; 35.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 6.
DR SUPFAM; SSF46966; Spectrin repeat; 32.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0G2K9T4};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 22..125
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 138..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 812..869
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 7029..7064
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7065..7100
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7105..7183
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 1981..2002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2102..2124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2763..2785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2836..2908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3012..3035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3153..3191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3228..3253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4590..4610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6939..6969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7199..7382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 421..473
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 990..1017
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1347..1377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3596..3630
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4014..4108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4154..4235
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4861..4916
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5046..5099
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5368..5395
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6079..6106
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2763..2778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4590..4606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7218..7297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7329..7382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7382 AA; 834790 MW; 1E703387C0DD01FC CRC64;
MNAYKYQKFL EGLNNLRDER DRVQKKTFTK WVNKHLMKVR KHINDLYEDL RDGHNLISLL
EVLSGIKLPR EKGRMRFHRL QNVQIALDFL KQRQVKLVNI RNDDITDGNP KLTLGLIWTI
ILHFQISDIY ISGESGDMSA KEKLLLWTQK VTAGYTGIKC TNFSSCWSDG KMFNALIHRY
RPDLVDMERV QIQSNRENLE QAFEVAERLG VTRLLDAEDV DVPSPDEKSV ITYVSSIYDA
FPKVPEGGEG ISATEVDSRW QEYQSRVDSL IPWIRQHTIL MSDKSFPQNP VELKALYNQY
IHFKETEILA KEREKGRIKE LYKLLEVWIE FGRIKLPQGY HPNHVEEEWG KLIVEMLERE
KSLRPAVERL ELLLQIANKI QNGALNCEEK LTLAKNTLQA DAAHLESGQP VQCESDVIMY
IQECEGLIRQ LQVDLQILRD EKYYQLEELA FRVMRLQDEL VTLRLECTNL YRKGHFTSLE
LVPPSTLTTT HLKAEPLNKT THSSSTSWFR KPMTRTELVA ISSSEDEGSL RFVYELLSWV
EEMQMKLERA EWGNDLPSVE LQWETQQHIH TSVEELGSSV KEARLYEGKM SQNFHTSYVE
TLGKLETQYC KLKETSSFRM RHLQSLHKFV SKATAELIWL NGKEEEELAC DWSDSNPNIS
AKKAYFSELT MELEGKQDVF RSLQDTAELL SLENHPAKQT VEAYSAAVQS QLQWMKQLCL
CVEQHIKENA AYFQFFSDAR DLESFLRNLQ DSIKRKYTCD HNTSLSRLED LLQDSMDEKE
QLIQSKSSVA SLVGRSKTIV QLKPRNPDHV LKSTLSVKAI CDYRQIEITI CKNDECVLED
NSQRTKWKVI SPTGNEAMVP SVCLLIPPPN TEAIDVASRV EQSYQKVMAL WHQLHINTKS
LISWNYLRKD IDAVQTWNLE KLRSSAPGEC HQVMKNLQAH YEDFLQDSHD SALFSVADRL
RIEEEVEACK THFQQLMESM ENEDKEETLA KVYISELKNI RLRLEECEQR LLKQIQSSAS
SKTDRDARQD VALRIAEQEH VQEDLKHLRS DLDAVSVKCT TFLQQSPSGS SATTLRSELN
LMVEKMDHVY GLSIVCLNKL KTIDVIVRSI QDAELLVKGY EIKLSQEEAV PADLSALESH
RTTLQHWLSD VKDKNSVFSV LDEEISKAKA VAEQLHHRAA EPNLDLERYQ EKGSQLQERW
HRVIAQLETR QSEVESIQEV LRDYRACHGT LIKWIEETTA QQEMMKPGQA EDSRVLSEQL
SQQTELFAEI ERNQTKLDQC QKLSQQYSTT VKDYELQLMT YKAFVESQQK SPGKRRRMIS
SSDAITQEFM DLRTRYTALV TLTTQHVKYI SDALRRLEEE EKVVEEEKQE HVEKVKDLLG
WVSTLARNTQ GTTTSSRTSA STDIEKAILE QQVLAEELTT KKEQVSEAIK TSQIFLAKHG
HKLSEREKEQ ISEQLCALNK TYHDLCDGSA NQLQQLQSEL AQQTEQKGCR AVAGVIDLGT
VEIFPIFRAM QKGLIDQDTG LVLLESQVIM SGLIAPENSE KLSLEEGLTR NLISLPMYQH
LLGLRDSLSL ISSLTGTQGS LSVVEAIEKK IVSERFGLKV LEVHLATGGF SLPPSENYIN
LEEAFHQGFI ASWLHSELQS HLRTSKNLID PNTAEKVGLL ELMQRCISHQ ESGLKLLPVK
QLAGGMVSLK SGGKVSIFRA VQEGLIDRQV TVRLLEAQLF AGGIVDPRTG HRLTAEEAVR
HNLIDQDMAC AILIRQLQTG GIIDTATGER MTIDEAVTNN LVAAKIALVI LESLWSFMGL
LLPESGEILP ITDALEQGIV SNELAHKILH NRQQIEALFL PTITEVWSWE KATESGILDK
DLANNLRSVC IPDMRPHIQL ADSAEQSKVG VAAGKPPLSC QREGRTSREE KLLFQLMTHS
YINAHTGQRL LLLDQELVEM LTSRDEYQVG LPEVFEIQPQ RLDTSKDLQE LDPGTISQIS
SARKPCESQF PSQSKGYPSQ ENCTQAKGER SVIGRECSSA ESPERELFVG EQGAITENVG
SLKVINKVKL ELQSPLLGSR KEEQTEMFSE ENVSSDPLLV ECPEGSEDMS LVLDKDLSTE
KSKCQAPTKS SFTRHKEQVK TVKADHIPSE TGIPLTKSQN KTSQVQVDAS VSLKSEFKSE
YDEKELNETL LVKGSHKQSQ EGQSVPDGQM VVLEKADTED NGDEPSLLCS SPFEDATLST
LSAQLQDGGI FHEETGQKLL LNEAIAQGLV SSHTAVKLMG KLNMFRGFFD SQTCESLTTE
EVIDEGLMDE KLLCNVLMSD KAISGILDPR THSLCSVQEA VAAGLLDKET ATRILEGQVI
TGGIVDLKRG KRLSVTLASN LGLVDTTDQT ELINLEKATK GRGAEKAVKE RLIGLQMETT
GLLDPESKAP LTVLQSIDRG LIEREEAIYQ LTKQVLDGGI IHHISGLRLS VDNAFKHGMI
GEDVARQLRK VENFNHHQFF HPQTKEALSF SEAIKLDLVS PDLKREIQEI LDFSENLGDL
IYGQKLTSVK ANKEESLANK TALPSRVIHG VIDPESCTTI PYSELVKKCR IDIESGWRYL
EVIPLSDIKD EMSNKVLTPS EAIQRGKVDF GSMLKVLEAQ ANTGGIIDMA TGKRVTLASA
LEQKLIDENM ARIIASHQVL TGGIIDIYND QRVTLNDAVE KRLISPELAT MIQADTLGKQ
GGTGVCELKG EFLRNEFRKA TRESYDKEKH EGVLQVGSQC AQEKANVRVS YGVKVGKGKK
ISVEMEGQRQ DEEKASSDNE VSASIVSPGG LEGESTHQVL VTHPCSGSSD LKLIEEARSP
EVEQEEAVAR MKMTPHVNRS TPGLDAGEAR DCPGRVGSKG QESKHEPAGK LSSVQAANVE
VGRRGRRETG GEERVQTNKV AAGPSEEELD QEVTIGDEHG SFVKSQPMKT IGNDRGKEGG
REKDFSLVCK TEGFPSQMTF KDASLENQNA LMFFSEGETK TVNLCSILKQ REKLSQETAS
IVQKEPFSSE IPRPERLNSQ ESDGESHISD MPCISKGPMA AQITTRQETT DEQDLSITSK
TAETKDRIFP SKNYKEKLLQ EIPMDSTRAH KLKESTVSTL DTEGLGYLDS SDIKALHEDS
RADREFSGHQ KSKITTTQEV KFLEVVNPLV RDAEGHRGSS KDRVAQRGPR TLASLLPEKL
PAGTAQSENT KQHDTVIIAT TPEMREEMPL SLPCSPLKVD EQIPKEKHKE LPGDERASCM
ATPSGKGSEG VKPAPCRATQ NVFTRRLCLE HDEKLVSYLS LLRDIEMRTK QIQPLELSVA
ELQDLLGQAK VLDRELKDLS TVVSQELECV DQIVISQPQE VPAQLLKALE KDAKNLQKSL
GSVRDSWSSR SLHLHNAVEV KKTTVLNWHK ELEGKLQDLK AWVDRTSLTL HSKGCDTQTD
ADSLSPTLQG YEDMKQSVAE RKSQLDALAL DTQLFISEHP QGLSLQQNQQ MLQFLSELQT
SFQGLVEHTA AQKDVVQGHL QQVQQEVQVK TLQKQQDTCH KKLEDLRSWV RQAERALERH
RGRASQQELS ALQQNQSDLK DLQGDIQNHS TSFATAVKDI EGFLEENQNK LSPQELTALR
EKLYQAKEQY EGLQDRTREA QKELEEAVTS ALQQETEKSK AATELAENRR KIDALLDWVT
SVGSSDRQPQ TSLPGTEQFS GACLEKQTLD ATDGCVDVNQ VPEKLDRQYE LMKARHQELL
SQQQNFIVAT QSAQSFLDQH SHNLTPEERQ MLQEKLGELK EQYAASLAQS EAKLRQTQTL
RDELQKFLQD HREFENWLER SENELDGMHT GGSSPEALNS LLKRQGSFSE DVISHKGDLR
FVTISGQKVL ETENNFEEGQ EPSPTRNLVN EKLKDATERY TTLHSKCTRL GSHLNMLLGQ
YQQFQSSADS LQAWMLTCEA SVEKLLSDTV ASDPGILQQQ LATTKQLQEE LAEHQVPVEK
LQKAAHDLMD IEGEPSLDCT PIRETTESIF SRFQSLSCSL AERSALLQKA IAQSQSVQES
MESLLQSMKE VEQNLEGEQV AALSSGLIQE ALANNMKLKQ DIARQKSSLE ATREMVTRFM
ETADGNSAAV LQDRLAELSQ RFHRLQLQQQ EKESGLKKLL PQAETFEQLS SKLQQFVEHK
NRLLASGNQP DQDIAHFSQH IQELTLEMED QKENLGTLEH LVTALGSCGF ALDLSQHQEK
IQNLKKDFTE LQKTVQEREK DASNCQEQLD EFRKLIRTFQ KWLKETEGNV PPAETFVSAK
ELEKQIEHLK GLLDDWAGKG VLVEEINTKG TALESLIMDI TAPDSQAKTD LTEIQCDMSD
VNSKYDKLGD ALRERQESLQ TVLSRMEEVQ KEASSVLQWL ESKEEVLKGM DASLSPTKTE
TVKAQAESNK AFLAELEQNS PKIQKVKEAL AGLLEAYPNS QEAENWRKMQ EDLNSRWEKA
TEVTVARQKQ LEESASHLAC FQAAESQLRP WLMEKELMMG VLGPLSIDPN MLNAQKQQVQ
FMLKEFEARR QQHEQLTEAA QGILTGPGDV SPSASQVHKD LQSISQKWVE LTDKLNSRST
QIDQAIVKST QYQDLLQDLS EKVKAVGQRL SGQSAISTQP DAVKQQLEET SEIRSDLGQL
DDEMKEAQTL CQELSLLIGE QYLKDELKKR LETVALPLQG LEDLAADRMN RLQAALASTQ
QFQQMFDELR TWLDEKQSQQ AKNCPISAKL ERLQSQLQEN EEFQKNLNQH SGSYEVIVAE
GESLLLSVPP GEEKKTLQNQ LVELKSHWED LNKKTVDRQS RLKDCMQKAQ KYQWHVEDLV
PWIKDCKSKM SELQVTLDPV QLESSLLRSK AMLNEAEKRR SLLEILNSAA DILINSSEID
EDEIRDEKAG LNQNMDAITE ELQAKTGSLE EMTQRLKEFQ ESFKNIEKKV EGAKHQLEIF
DALGSQACSN KNLEKLKAQR EVLQALDPQV DYLRDFTRGL VEDAPDGSDA SPLVHQAELA
QQEFLEVKQR VNSSCLTMEN KLEGIGQFHC RVREMFSQLA DLDDELDGMG AIGRDTDSLQ
SQIEDIRLFL NKIQALRLDI EDSEAECRKM LEEEGTLDLL GLKRELEALN KQCGKLTERG
KARQEQLELT LGRVEDFYSK LKALNDAATA AEEGEALQWI VGTEVDVINQ QLADFKMFQK
EQVDPLQVKL QQVNGLGQGL IQSAGKTCDV QGLEHDMEEV NTRWNTLNKK VAQRIAQLQE
ALLHCGKFQD ALEPLLSWLT DTEELIANQK PPSAEYKVVK AQIQEQKLLQ RLLDDRKATV
DMLQAEGGRI AQAAELADRE KITGQLESLE CRWTELLSKA AARQKQLEDI LVLAKQFHET
AEPISDFLSV TEKKLANSEP VGTQTAKIHQ QIIRHKALEE EIENHAADVQ QAVKIGQSLS
SLICPAEQGI MSEKLDSLQA RYSEIQDRCC RKASLLEQAL FNARLFGEDE VEVLNWLAEV
EDKLSAVFVK DYRQDVLQKQ HADHLALNEE IINRKKNVDQ AIKNGQALLK QTTGEEVLLI
QEKLDGIKTR YADITVTSSK ALRTLEQARQ LATKFHSTYE ELTGWLREVE EELAASGGQS
PTGEQIPQFQ QRQKELKKEV MEHRLVLDTV NEVSHALLEL VPWRAREGLD KLVSDANEQY
KLVSDTVGQR VDEIDAAIQR SQQYEQAADA ELAWVAETKR KLMALGPIRL EQDQTTAQLQ
VQKAFSIDII RHKDSMDELF SHRGEIFSTC GEEQKAVLQE KTECLIQQYE AVSLLNSERY
ARLERAQVLV NQFWETYEEL SPWAEETLAL IAQLPPPAVD HEQLRQQQEE MRQLRESIAE
HKPHIDKILK IGPQLKELNP EEGKMVEEKY QKAENMYAQI KDEVRQRALA LDEAVSQSAQ
IAEFHDKIEP MLETLENLSS RLRMPPLIPA EVDKIRECIS DNKSATMELE KLQPSFEALK
RRGEELIGRS QGADKDLAAK EIQDKLDQMV FFWEDIKARS EEREIKFLDV LELAEKFWYD
MAALLTTIKD TQEIVHDLES PGIDPSIIKQ QVEAAETIKE ETDGLHEELE FIRILGADLI
FACGETEKPE VKKSIDEMNN AWENLNRTWK ERLEKLEDAM QAAVQYQDTL QAMFDWLDNT
VIRLCTMPPV GTDLNTVKDQ LNEMKEFKVE VYQQQIEMEK LNHQGELMLK KATDETDRDI
IREPLTELKH LWENLGEKIA HRQHKLEGAL LALGQFQHAL EELMGWLTHT EELLDAQRPI
SGDPKVIEVE LAKHHVLKND VLAHQATVET VNKAGNELLE SSAGDDASSL RSRLETMNQC
WESVLQKTEE REQQLQSTLQ QAQGFHSEIE EFLLELNRME SQLSASKPTG GLPETAREQL
DAHMELHSQL RAKEEIYNQL LDKGRLMLLS RGDSGSGSKT EQSVALLEQK WHVVSSKVEE
RKSKLEEALS LATEFQNSLQ EFINWLTLAE QSLNIASPPS LILNTVLSQI EEHKVFANEV
NAHRDQIIEL DQTGNQLKFL SQKQDVVLIK NLLVSVQSRW EKVVQRSIER GRSLDDARKR
AKQFHEAWKK LIDWLEDAES HLDSELEISN DPDKIKLQLS KHKEFQKTLG GKQPVYDTTI
RTGRALKEKT LLADDAQKLD NLLGEVRDKW DTVCGKSVER QHKLEEALLF SGQFMDALQA
LVDWLYKVEP QLAEDQPVHG DLDLVMNLMD AHKVFQKELG KRTGTVQVLK RSGRELIESS
RDDTTWVKGQ LQELSTRWDT VCKLSVSKQS RLEQALKQAE EFRDTVHMLL EWLSEAEQTL
RFRGALPDDT EALQSLIDTH KEFMKKVEEK RVDVNAAVAM GEVILAVCHP DCITTIKHWI
TIIRARFEEV LTWAKQHQQR LETALSELVA NAELLEELLA WIQWAETTLI QRDQEPIPQN
IDRVKALITE HQSFMEEMTR KQPDVDRVTK TYKRKNIEPT HAPFIEKSRS GSRKSLNQPT
PPPMPILSQS EAKNPRINQL SARWQQVWLL ALERQRKLND ALDRLEELKE FANFDFDVWR
KKYMRWMNHK KSRVMDFFRR IDKDQDGKIT RQEFIDGILA SKFPTTKLEM TAVADIFDRD
GDGYIDYYEF VAALHPNKDA YRPTTDADKI EDEVTRQVAQ CKCAKRFQVE QIGENKYRFF
LGNQFGDSQQ LRLVRILRST VMVRVGGGWM ALDEFLVKND PCRARGRTNI ELREKFILPE
GASQGMTPFR SRGRRSKPSS RAASPTRSSS SASQSNHSCT SMPSSPATPA SGTKVISSTG
SKLKRPTPTF HSSRTSLAGD TSNSSSPAST GAKTNRADPK KSASRPGSRA GSRAGSRASS
RRGSDASDFD LLETQSACSD TSESSAAGGQ GSSRRGLTKP SKIPTMSKKT TTASPRTPCP
KR
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