GenomeNet

Database: UniProt
Entry: A0A0G2KAH9_RAT
LinkDB: A0A0G2KAH9_RAT
Original site: A0A0G2KAH9_RAT 
ID   A0A0G2KAH9_RAT          Unreviewed;      2574 AA.
AC   A0A0G2KAH9;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   30-AUG-2017, entry version 13.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSRNOP00000075403};
GN   Name=Itpr1 {ECO:0000313|Ensembl:ENSRNOP00000075403,
GN   ECO:0000313|RGD:2933};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000075403, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000075403, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075403,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000075403}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000075403};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000075403}.
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DR   EMBL; AABR07061705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07061706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07061707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSRNOT00000082723; ENSRNOP00000075403; ENSRNOG00000007104.
DR   RGD; 2933; Itpr1.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-RNO-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-RNO-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-RNO-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-RNO-418457; cGMP effects.
DR   Reactome; R-RNO-5578775; Ion homeostasis.
DR   Reactome; R-RNO-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000007104; -.
DR   ExpressionAtlas; A0A0G2KAH9; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 4.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2KAH9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2099   2121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2133   2151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2220   2245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2265   2287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2395   2418       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     48       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       56    112       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      119    198       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      204    260       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2512   2553       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2574 AA;  293631 MW;  6C8DCC56322BE8EA CRC64;
     VVIGDKVVLN PVNAGQPLHA SSHQLVDNPG CNEVNSVNCN TSWKIVLFMK WSDNKDDILK
     GGDVVRLFHA EQEKFLTCDE HRKKQHVFLR TTGRQSATSA TSSKALWEVE VVQHDPCRGG
     AGYWNSLFRF KHLATGHYLA AEVDPDFEEE CLEFQPSVDP DQDASRSRLR NAQEKMVYSL
     VSVPEGNDIS SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM
     LKIGTSPLKE DKEAFAIVPV SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK
     LLEDLVYFVT GGTNSGQDVL EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM
     LRLEELGDQR HAPFRHICRL CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI
     TALLHNNRKL LEKHITAAEI DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA
     VLNPTNADIL IETKLVLSRF EFEGVSTGEN ALEAGEDEEE VWLFWRDSNK EIRSKSVREL
     AQDAKEGQKE DRDVLSYYRY QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY
     DLRASFCRLM LHMHVDRDPQ EQVTPVKYAR LWSEIPSEIA IDDYDSSGAS KDEIKERFAQ
     TMEFVEEYLR DVVCQRFPFS DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIL
     DCVHVTTIFP ISKMTKGEEN KGSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV
     KQAEPEKEDI MVMDTKLKII EILQFILNVR LDYRISCLLC IFKREFDESN SQSSETSSGN
     SSQEGPSNVP GALDFEHIEE QAEGIFGGRK ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL
     VSGALQLLFR HFSQRQEVLQ AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK
     GQGPDEPMDG ASGENEHKKT EEGTSKPLKH ESTSSYNYRV VKEILIRLSK LCVQESASVR
     KSRKQQQRLL RNMGAHAVVL ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL
     HKHINLFLNP GILEAVTMQH IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI
     VKAEGKFIKK CQDMVMAELV NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLMYHI
     HLVELLAVCT EGKNVYTEIK CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV
     EMKEIYTSNH MWKLFENFLV DICRACNNTS DRKHADSVLE KYVTEIVMSI VTTFFSSPFS
     DQSTTLQTRQ PVFVQLLQGV FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD
     SQVNNLFLKS HNIVQKTAMN WRLSARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR
     PLVQAELSVL VDVLHRPELL FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL
     QTLREMMTKD RGYGEKQISI DELENAELPQ PPEAENSTEQ ELEPSPPLRQ LEDHKRGEAL
     RQILVNRYYG NIRPSGRRES LTSFGNGPLS PGGPSKPGGG GGGPGSGSTS RGEMSLAEVQ
     CHLDKEGASN LVIDLIMNAS SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF
     FKVFYDRMKV AQQEIKATVT VNTSDLGNKK KDDEVDRDAP SRKKAKEPTT QITEEVRDQL
     LEASAATRKA FTTFRREADP DDHYQSGEGT QATTDKAKDD LEMSAVITIM QPILRFLQLL
     CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDCICGSTTG GLGLLGLYIN EKNVALINQT
     LESLTEYCQG PCHENQNCIA THESNGIDII TALILNDINP LGKKRMDLYL ELRNNASKLL
     LAIMESRHDS ENAERILYNM RPKELVEVIK KAYMQGEVEF EDGENGEDGA ASPRNVGHNI
     YILAHQLARH NKELQTMLKP GGQVDGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC
     EFLTKESKLR IYYTTERDEQ GSKINDFFLR SEDLFNEMNW QKKLRAQPVL YWCARNMSFW
     SSISFNLAVL MNLLVAFFYP FKGVRGGTLE PHWSGLLWTA MLISLAIVIA LPKPHGIRAL
     IASTILRLIF SVGLQPTLFL LGAFNVCNKI IFLMSFVGNC GTFTRGYRAM VLDVEFLYHL
     LYLLICAMGL FVHEFFYSLL LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS
     IVGYLFFKDD FILEVDRLPN ETAGPETGES LANDFLYSDV CRVETGENCT SPAPKEELLP
     VEETEQDKEH TCETLLMCIV TVLSHGLRSG GGVGDVLRKP SKEEPLFAAR VIYDLLFFFM
     VIIIVLNLIF GVIIDTFADL RSEKQKKEEI LKTTCFICGL ERDKFDNKTV TFEEHIKEEH
     NMWHYLCFIV LVKVKDSTEY TGPESYVAEM IRERNLDWFP RMRAMSLVSS DSEGEQNELR
     NLQEKLESTM KLVTNLSGQL SELKDQMTEQ RKQKQRIGLL GHPPHMNVNP QQPA
//
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