GenomeNet

Database: UniProt
Entry: A0A0G2KQB9_DANRE
LinkDB: A0A0G2KQB9_DANRE
Original site: A0A0G2KQB9_DANRE 
ID   A0A0G2KQB9_DANRE        Unreviewed;      4592 AA.
AC   A0A0G2KQB9;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSDARP00000134587};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000134587, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000134587, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134587,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000134587}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134587};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000134587}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CABZ01061695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01061696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01061697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01061698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01061699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01061700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01084953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01084954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01084955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01084956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000102901; -.
DR   Ensembl; ENSDART00000167726; ENSDARP00000134587; ENSDARG00000098856.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Proteomes; UP000000437; Chromosome 12.
DR   Bgee; ENSDARG00000098856; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3117   3137       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3149   3174       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3904   3923       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4125   4146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4202   4221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4317   4333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4339   4363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4384   4406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4469   4492       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       10     65       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       72    117       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      125    180       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      186    245       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      251    309       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      494    710       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      926   1124       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1256   1462       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3649   3684       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4592 AA;  519613 MW;  9FB46814124E921D CRC64;
     VFQTAQGGGH RTLLYGHAVL LRHSYSGMYL CCLSTARSST DKLAFDVGLQ EDATGEACWW
     TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNGS LHVDAAFQQT LWSVVPICSG
     SEVAQGFLIG GDVLRLLHGH MDECLTVPSG EHGEEQRRTV HYEGGAVSIH ARSLWRLETL
     RVAWSGSHIR WGQPFRLRHV TTGKYLSMMD DQGLLLMDKE KADVKSTAFC FRSSKEKLDF
     GLRKEMDGMG VPDIKYGDSV CYIQHVDAGL WLTYQSVDAK CARMGGVQRK VSLQHHEGHM
     DDGLTLSRSQ HEESRTARVI RSTVFLFNRF IRGLDTLSKK GKTSTLDLPI ESVSLSLQDL
     IGYFQPPDEH LEHEDKQNRL RALKSRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG
     KEAGESWKSI LNSLYELLAA LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL
     VESPEALNII KEGHIKSIVK IPDYMCADVQ VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG
     RDLLLQTRLV NHVSSMRPNI FLGVSEGSAQ YKKWYYELIV DHVDPFVTAE ATHLRVGWAS
     TQGYGPYPGG GEGWGGNGVG DDLYSYGFDG LHLWAGCVAR SVSSPNQHLL RAEDVVSCCL
     DLSAPSISFR INGQPVQGMF ENFNSDGLFF PVVSFSAGVK VRFLLGGRHG EFKFLPPSGY
     APCFEAVLPR EKLRVEHSQE YKQDHGNTRD LLGPTVTLSQ AAFTPTPVDT SQIVLPPHLE
     RIREKLAENI HELWVMNKID LGWTYGAVRD DNKRQHPCLV EFSRLPEQER SYNLQMSQET
     LKTLLALGCH VGVADERAAE KVKNLKLSAK YELSSGYKPA PMDLCHIKLA STQEAMVDKL
     AENAHNVWAR DRIRQGWTYG IQQDIKNKRN PRLVPYVLLD ERTKKSNKDS LREAVRTLLG
     YGYNLEAPDQ DHGTTREDVG NLSAERFRIF RAEKTYCVNG GKWYFELEVV TAGEMRVGWA
     RPGCLPDQEL GADEQAFVFD GFKAQRWHQG NEHFGRSWQS GDVVGCMVDM NERTMMFTLN
     GEVLLDDSGS ELAFKDFEVW EGFIPVCSLG VSQVGRMNFG KDVSTLKYFT ICGLQEGYEP
     FAVNMNRDLT MWISKRLPQF TPVPLIHEHI EVTRIDGTVE SPPCLKVTQR SFGSQNSHTD
     IMFYRLSMPI ECSEAFARSP GGTLAANGSF FSPKRDLEDF ETVSDFEVLM KTPHSHMSSN
     GPDRERDEFN NHKDHNQEKP SKIKQRFMLK RTKPDMNSSS SSARLSEEVL ADEKDDCENL
     IQTSTYYYSV RIFPGQEPSS VWVGWVTSDF HQYDTAFEIS NVRTVTVTLG DEKGKVHESI
     KRSNCYMVWA GECTSPGQGR SNNGLEIGCL VDTANGLLTF TSNGKELSTY YQVEPSTKLF
     PAVFAQATSP NVFQFELGPL VAQIMPLSAG LFKSERKNVV PQCPPRLHVQ FLTPVLWSRV
     PNQFLRSEVT RVNERLGWMV QSLEPLHFIN FKAKKKALKS VDILELTEQQ DLLKFHYHTL
     RLYSAICALG NNRVAHALCS HVDEAQLLYA IQNKYMPGLL RTGYYDLLID IHLSSYATAR
     LMMNSEYIVP MTPETKSITL FPNEKKKHGL PGIGLSTSLQ PRMRFSSPSF VGFNGSGGVD
     CFQYSPEFPL ETLKSRTMEM LTEAVREGSL HVRDPVGGST EFLFVPLIKL FYTLLIMGIF
     HNGDLKTILQ LIEPSVFSQD SGADGGGGSV GDGCGRGQLE GGVVDDGLRG KMPKEGLLQM
     KLPEPVKLQM CHLLQYLCDC QVRHRIEAVV AFSDDFVANL QENQRFRYNE VMQALNMSAA
     LTARKTKEFR SPPQEQINML LNFKDEKQDC PCPEDIREQL LDFHEDLMTH CGIETDDDKS
     GDGDSDFTIR GRLMSLVEKV TYLKKKMTDL PKKKKSKKPS TLQQLISETM VRWAQESVIE
     DPELVRAMFV LLHRQYDGIG GQVRALPKTY TINAVSVEDT ISLLASLGQI RSLLSVRMGR
     EEEKLMIHGL SDIMNNKVFY QHPNLMRALG MHETVMEVMV NVLGGGESKE ITFPKMVANC
     CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASPSMRG STPLDVAAAS VMDNNELALA
     LREPDLEKVV QYLAGCGLQS CVMLMSKGYP DIGWNPVEGE RYLDFLRFAV FCNGESVEEN
     ANVVVRLLIR RPECFGPALR GEGGNGLLAA IEEAIKISED PSRDGPSPTT EESRTLNDVM
     EEEEDDTIHM GNAIMTFYAA LIDLLGRCAP EMHLIHAGKG EAIRIRAILR SLIPIEDLVG
     VISIPFLMPT LAKDGSVIEP DMSAGFCPDH KAAMVLFLDR VYGIEDQNFL LHLLEVGFLP
     DLRAAASLDT AALSATDMAL ALNRYLCTAV LPLLTKCAPL FAGTEPFASL IDSLLHTVYR
     LSKGCCLTKA QRDAIEECLL AVCGKLRPSM MQHLLRRLVF DVPVLNEHTK MPLKLLTNHY
     ERCWKYYCLS GGWGSFGAAS EEELHLSRKL FWGIFDALAR KKNDPELFKL ALPCLSAVGG
     ALPPDYMESN YVAMMEKQSS MDAEGNFNPQ PADTSSVVVP EKLDHFINKY AEYSHEKWSM
     EKFAVGWVHG EQMCESSKVH PLLKPYKCLS EKDKEVYRWP IRESLKTMLS WGWSIERMRE
     SDASTLHNRT RRISLSSQRS IEGAHGFSPR PVDMSNVTLS RDLHSMAELL AENYHNIWAQ
     KKKLELESKG GGSHPLLVPY DTLTAKEKSK DREKAQDILK FFQINGYSVS RAMKEQDLDT
     PSIEKRFAYT FLQQLITYVD EAHGHMLEFD AGIRPKGEKI PHEQQIKFFG KVVLPLVDQY
     FKNHRLYFLS TAVRPISSGG HASNKEKEMV TSLFCKLGVL VRHRISLFGN DATSIVNCLH
     ILGQTLDART VMKTGQDSVK AALRAFFDNA AEDLEKTMEN LRQGQFTHTR SQPKGVTQII
     NYTTVALLPV LSSLFEHIGQ NLFGEDLILD DVQVSCYRIL NNLYSLGTSK SIYVERQRPA
     IGECLAAFSS AFPVAFLEPS LNKHNTYSIY NCKGSRERAG SMNIIENVWC SCVCDVMFAY
     VWCVCGGSDV FACLCACCKY SGYVFRCVFC VLVWFMSCGV YVCACVGVCV QVVFVRLCVC
     VCGSFNSRFL PCSDDLIPDY VSDSHPTLMI RFLMITFCPD DMIPDSHPVL IIRFLILIIF
     RHRAVNLFLQ GYEKSWIETE EHYFEDKLIE DLAKPGVEEP PEEDEMTKNI DPLHQLIQLF
     SRTALTEKCK LEEDHLYMAY ADIMAKSCHD EEEEDEVKSF EEKEMEKQKL LYQQARLHDR
     GAAEMVLQTI SASKGEMGPM VASTLKLGIA ILNGGNSTVQ QKMLDYLKDK RDVGFFQSLA
     GLMQSCRYIR LNSLVRWPLA QRLGVCTAKS ASEKVMQDDE FTCDLFRFLQ LLCEGHNSDF
     QNYLRTQTGN NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDVIDEQGQR NFSKAINVAK
     QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ IELLKELMDL
     QKDMVVMLLS MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDAFKE
     YDPDGKGVIS KRDFHKAMES HKHYTQSETE FLLSCAETDE NELLDYEEFV ERFHEPAKDI
     GFNVAVLLTN LSEHMPHDSR LQTFLELAES VLNYFQPYLG RIEIMGSAKR IERVYFEISE
     SSRTQWEKPQ VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA RMSDAGERSA
     SKEDSEREKP EEETPEMGFF SITTVRTALF ALRYNVMLLM KVLSMKSLKK QVKKAKKMTV
     KDMVTTLVSF YWSVLLGLLH FAFSVARGFF RIIYNSFLGG SLVEGAKTMK VSELLANMPD
     PTQDEVRGEM EDGEKKPVDK TSPEEDLADL TVATDETDLL SDIFGLDLKR EGGQYKLMPH
     NPNASLTDLL NTPVPPPPTP SPELRRRHHT KGSSSSTDNN DAAEETKSVP EKAEGENVEK
     AQKKKEEAVK RKVRQHYEPD LQESAFWKKI IAYQRKLLNY FARNFYNMRM LALFVAFAIN
     FILLFYKVST SSAVTEGKEV LFSASSDTSV QWDPLSGSSS RPVTVHFVLE ESSGYMEPTL
     RILAILHTVI SFFCIIGYYC LKVPLVIFKR EKEVARKLEF DGLYITEQPS EDDIKGQWDR
     LVINTQCSIK KNYVNYLIPS NLRFKTGSIS FYLRIIKIVI DDAEFDSNKY KNVHSKFSFV
     CSCIFHLFFL SALPFLFSLS IFCSFFCSLF VLLLCHFYSY MFLNRDFTIL MIFLITHSQT
     QMTSVLLQGV LLVLTVGLLA VVVYLYTVVA FNFFRKFYNK SEDGESPDMK CDDMLTCYMF
     HMYVGVRAGG GIGDQIEDPA GDEYEIYRII FDITFFFFVI VILLAIIQGL IIDAFGELRD
     QQEQVKEDME TKCFICGIGN DYFDTVPHGF ETHTLQEHNL ANYLFFFMYL INKDETEHTG
     QESYVWKMYQ ERCWEFFPAG DCFRKQYEDQ LN
//
DBGET integrated database retrieval system