ID A0A0G2ZAM8_9BACT Unreviewed; 310 AA.
AC A0A0G2ZAM8;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN ORFNames=IX53_01015 {ECO:0000313|EMBL:AKI96634.1};
OS Kosmotoga pacifica.
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae;
OC Kosmotoga.
OX NCBI_TaxID=1330330 {ECO:0000313|EMBL:AKI96634.1, ECO:0000313|Proteomes:UP000035159};
RN [1] {ECO:0000313|EMBL:AKI96634.1, ECO:0000313|Proteomes:UP000035159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLHLJ1 {ECO:0000313|EMBL:AKI96634.1,
RC ECO:0000313|Proteomes:UP000035159};
RA Jiang L.J., Shao Z.Z., Jebbar M.;
RT "Complete Genome Sequence of Kosmotoga pacifica SLHLJ1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to
CC yield dTDP-L-rhamnose. {ECO:0000256|RuleBase:RU364082}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-
CC rhamnose + H(+) + NADPH; Xref=Rhea:RHEA:21796, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57510, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:62830; EC=1.1.1.133;
CC Evidence={ECO:0000256|RuleBase:RU364082};
CC -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC {ECO:0000256|RuleBase:RU364082}.
CC -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase family.
CC {ECO:0000256|ARBA:ARBA00010944, ECO:0000256|RuleBase:RU364082}.
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DR EMBL; CP011232; AKI96634.1; -; Genomic_DNA.
DR RefSeq; WP_047753769.1; NZ_CP011232.1.
DR AlphaFoldDB; A0A0G2ZAM8; -.
DR STRING; 1330330.IX53_01015; -.
DR KEGG; kpf:IX53_01015; -.
DR PATRIC; fig|1330330.3.peg.201; -.
DR OrthoDB; 9803892at2; -.
DR UniPathway; UPA00124; -.
DR Proteomes; UP000035159; Chromosome.
DR GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR NCBIfam; TIGR01214; rmlD; 1.
DR PANTHER; PTHR10491; DTDP-4-DEHYDRORHAMNOSE REDUCTASE; 1.
DR PANTHER; PTHR10491:SF4; METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|RuleBase:RU364082};
KW Oxidoreductase {ECO:0000256|RuleBase:RU364082}.
FT DOMAIN 1..306
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 310 AA; 34772 MW; 2DAC45A91BC45861 CRC64;
MRILITGANG QLGKDFQKLF DREGIDCVAT DFITAGGTQQ AASGEQRSNN QQLSTGDQQL
LHLDITDLQS IRKLATDIKP DVIINCAAYN AVDKAEVEWE KAYTINGVGV RNLAIVANEL
NAILVHYSTD YVFDGNKKEP YTIFDLPNPL SRYGESKFLG EKLLVQTGGK FILIRTSWVF
GAGNINFAKK VLEWAQKNGE LKIVTDEISV PTYTVDLAQA TWTIINKRAY GLYHISNEGE
CSRYEYASYI LEKIGWHGKL LPAKQKDFDF PAKRPKYSKL SNFGLKETVN IEMPDWKNAV
DRFLKETGAV
//
