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Database: UniProt
Entry: A0A0G3AE06_9ACTN
LinkDB: A0A0G3AE06_9ACTN
Original site: A0A0G3AE06_9ACTN 
ID   A0A0G3AE06_9ACTN        Unreviewed;       664 AA.
AC   A0A0G3AE06;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-JUL-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AKJ12058.1};
GN   ORFNames=ABB07_19065 {ECO:0000313|EMBL:AKJ12058.1};
OS   Streptomyces incarnatus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=665007 {ECO:0000313|EMBL:AKJ12058.1, ECO:0000313|Proteomes:UP000035366};
RN   [1] {ECO:0000313|EMBL:AKJ12058.1, ECO:0000313|Proteomes:UP000035366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL8089 {ECO:0000313|Proteomes:UP000035366};
RX   PubMed=26159526;
RA   Oshima K., Hattori M., Shimizu H., Fukuda K., Nemoto M., Inagaki K.,
RA   Tamura T.;
RT   "Draft Genome Sequence of Streptomyces incarnatus NRRL8089, which
RT   Produces the Nucleoside Antibiotic Sinefungin.";
RL   Genome Announc. 3:e00715-15(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP011497; AKJ12058.1; -; Genomic_DNA.
DR   EnsemblBacteria; AKJ12058; AKJ12058; ABB07_19065.
DR   PATRIC; fig|665007.5.peg.4084; -.
DR   Proteomes; UP000035366; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035366};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035366}.
FT   DOMAIN      357    485       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      571    640       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     365    372       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   664 AA;  73761 MW;  8005ECFC15E42651 CRC64;
     MWPRVLEQLL GEGRGQGVEA KDEHWIRRCQ PLALVADTAL LAVPNEFAKG VLEGRLAPVV
     SETLSRECGR PIRIAITVDD SAGEPPAPAA PVPQPPKPRY EEPELPSGPS YEERTYEERP
     YEGYGRHRAA EQPPAEQQHR ADPLPTGRPD QLPVVRPAYP SEYQRREPGT WPRPAQDEYG
     WQQPRLGFPE RDPYASPSSQ DAYGSGPEGY GSGPDSYGSP SPDYRSKSMD RPSYDQQRGE
     YDGPRADYDS ARPDYDSARP EYDPSRTEYD QRDPVRRELP EQPAVGGPAH RGGPGRPDLP
     TTGAPGPLAA QPAPASGPGE PTARLNPKYL FDTFVIGASN RFAHAAAVAV AEAPAKAYNP
     LFIYGESGLG KTHLLHAIGH YARSLYPGTR VRYVSSEEFT NEFINSIRDG KGDSFRKRYR
     EMDILLVDDI QFLADKESTQ EEFFHTFNTL HNANKQIVLS SDRPPKQLVT LEDRLRNRFE
     WGLITDVQPP ELETRIAILR KKAVQEQLNA PPEVLEFIAS RISRNIRELE GALIRVTAFA
     SLNRQPVDLG LTEIVLKDLI PGGEDSAPEI TATAIMAATA DYFGLTVDDL CGTSRGRALV
     TARQIAMYLC RELTDLSLPK IGAQFGGRDH TTVMHADRKI RALMAERRSI YNQVTELTNR
     IKNG
//
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