ID A0A0G3ASW1_9ACTN Unreviewed; 303 AA.
AC A0A0G3ASW1;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dihydrodipicolinate synthase {ECO:0000313|EMBL:AKJ13949.1};
GN ORFNames=ABB07_29080 {ECO:0000313|EMBL:AKJ13949.1};
OS Streptomyces incarnatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=665007 {ECO:0000313|EMBL:AKJ13949.1, ECO:0000313|Proteomes:UP000035366};
RN [1] {ECO:0000313|EMBL:AKJ13949.1, ECO:0000313|Proteomes:UP000035366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL8089 {ECO:0000313|Proteomes:UP000035366};
RX PubMed=26159526;
RA Oshima K., Hattori M., Shimizu H., Fukuda K., Nemoto M., Inagaki K.,
RA Tamura T.;
RT "Draft Genome Sequence of Streptomyces incarnatus NRRL8089, which Produces
RT the Nucleoside Antibiotic Sinefungin.";
RL Genome Announc. 3:e00715-e00715(2015).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; CP011497; AKJ13949.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G3ASW1; -.
DR STRING; 665007.ABB07_29080; -.
DR PATRIC; fig|665007.5.peg.6167; -.
DR Proteomes; UP000035366; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF19; 5-DEHYDRO-4-DEOXYGLUCARATE DEHYDRATASE 2-RELATED; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT ACT_SITE 144
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 169
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 56
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 303 AA; 32105 MW; C02399FE52268D41 CRC64;
MSGVTFETQR AALADVVAIP VTPFAADGSV DLAAHRALLR RLLDGGIGTL TPNGNTGEFY
ALTPEERRLV AESTIEEAGD RAAVLVGVGH DLPTAIASAR HARDLGAGMV MVHQPVHPYV
SAAGWVDYHR AIAEAVPELG VVPYIRNDRL AGARLVELAD HCPNVIGVKY AVPDAARFAA
FARDAGLDRF VWVAGLAEPY APSYFSAGAT GFTSGLVNVA PAVSLNMIEA LRSGDYPGAM
KVWEQIRRFE ELRAAHGSAN NVTVVKEALA ALGLCRRDVR PPSRPLPEDE RAEVAAIAAG
WSI
//
