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Database: UniProt
Entry: A0A0G3BPP4_9BURK
LinkDB: A0A0G3BPP4_9BURK
Original site: A0A0G3BPP4_9BURK 
ID   A0A0G3BPP4_9BURK        Unreviewed;       307 AA.
AC   A0A0G3BPP4;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=hydroxymethylglutaryl-CoA lyase {ECO:0000256|ARBA:ARBA00012910};
DE            EC=4.1.3.4 {ECO:0000256|ARBA:ARBA00012910};
GN   ORFNames=AAW51_4691 {ECO:0000313|EMBL:AKJ31382.1};
OS   Caldimonas brevitalea.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilaceae; Caldimonas.
OX   NCBI_TaxID=413882 {ECO:0000313|EMBL:AKJ31382.1, ECO:0000313|Proteomes:UP000035352};
RN   [1] {ECO:0000313|EMBL:AKJ31382.1, ECO:0000313|Proteomes:UP000035352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7029 {ECO:0000313|EMBL:AKJ31382.1,
RC   ECO:0000313|Proteomes:UP000035352};
RA   Tang B., Yu Y.;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA;
CC         Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074,
CC         ChEBI:CHEBI:57288; EC=4.1.3.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001651};
CC   -!- PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-
CC       methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-
CC       methylglutaryl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00005143}.
CC   -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC       {ECO:0000256|ARBA:ARBA00009405}.
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DR   EMBL; CP011371; AKJ31382.1; -; Genomic_DNA.
DR   RefSeq; WP_047196534.1; NZ_CP011371.1.
DR   AlphaFoldDB; A0A0G3BPP4; -.
DR   STRING; 413882.AAW51_4691; -.
DR   KEGG; pbh:AAW51_4691; -.
DR   PATRIC; fig|413882.6.peg.4899; -.
DR   OrthoDB; 9784013at2; -.
DR   UniPathway; UPA00896; UER00863.
DR   Proteomes; UP000035352; Chromosome.
DR   GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IEA:UniProtKB-EC.
DR   CDD; cd07938; DRE_TIM_HMGL; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000138; HMG_CoA_lyase_AS.
DR   InterPro; IPR043594; HMGL.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS01062; HMG_COA_LYASE; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:AKJ31382.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035352}.
FT   DOMAIN          6..273
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   307 AA;  32680 MW;  A293420A74B434B0 CRC64;
     MIPHQVRLVE VGPRDGLQNE KQPVAAADKI DLVHRLQAAG VREIEVTSFV SPKWVPQMAD
     NTEVMAGLQR RPGVRYSVLT PNMKGLEAAL ASRPDEIVVF GAASEAFSQR NINCSIAESI
     ERFQPVVQAA HAHGIKVRGA VSCALGCPYQ GEVSADEVER VARLMREIGV DHLGVADTIG
     VGTPKRVQRA MERALRHYPL SEVSGHFHDT YGQALANIYA CLELGVATFD ASVAGLGGCP
     YAKGATGNVA TEDVVFLLQG LDIDSGVDLD RLVDAGAFIS GVLGRKPVSR VGNAVLAKRP
     SLQESAA
//
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