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Database: UniProt
Entry: A0A0G3CLS8_9GAMM
LinkDB: A0A0G3CLS8_9GAMM
Original site: A0A0G3CLS8_9GAMM 
ID   A0A0G3CLS8_9GAMM        Unreviewed;       235 AA.
AC   A0A0G3CLS8;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-SEP-2017, entry version 16.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN   ORFNames=QQ39_13325 {ECO:0000313|EMBL:AKJ42924.1};
OS   Pragia fontium.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Budviciaceae; Pragia.
OX   NCBI_TaxID=82985 {ECO:0000313|EMBL:AKJ42924.1, ECO:0000313|Proteomes:UP000068021};
RN   [1] {ECO:0000313|EMBL:AKJ42924.1, ECO:0000313|Proteomes:UP000068021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24613 {ECO:0000313|EMBL:AKJ42924.1,
RC   ECO:0000313|Proteomes:UP000068021};
RX   PubMed=26159528;
RA   Snopkova K., Sedlar K., Bosak J., Chaloupkova E., Provaznik I.,
RA   Smajs D.;
RT   "Complete Genome Sequence of Pragia fontium 24613, an Environmental
RT   Bacterium from the Family Enterobacteriaceae.";
RL   Genome Announc. 3:e00740-15(2015).
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
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DR   EMBL; CP010423; AKJ42924.1; -; Genomic_DNA.
DR   RefSeq; WP_047781657.1; NZ_CP010423.1.
DR   EnsemblBacteria; AKJ42924; AKJ42924; QQ39_13325.
DR   KEGG; pfq:QQ39_13325; -.
DR   KO; K10763; -.
DR   Proteomes; UP000068021; Chromosome.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000068021};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468};
KW   Initiation factor {ECO:0000313|EMBL:AKJ42924.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:AKJ42924.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000068021}.
FT   DOMAIN       17    214       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   235 AA;  26496 MW;  A47E4E2751F691D7 CRC64;
     MFLNTSTQLS FPLYLSDDET FASFYPGENA SLLAAIHSAL HQEHSTYIYF WSGDAGGKSH
     LLRAACAELS QQGIAVGYVP LDKRTYFVPE VLDGMEQLAL VCIDNIECIA GDAEWEMAIF
     NLYNRILETG FTRLLISGET PPRQLNLSLP DLASRLDWGQ IYRLHPLSDD DKLQALILRA
     KLRGFELPED VGRFLLKRLD RDMRTLFATL DHLDSASITA QRKLTIPFVK EALDL
//
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