ID A0A0G3GN43_9CORY Unreviewed; 927 AA.
AC A0A0G3GN43;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=CRISPR-associated helicase Cas3/CRISPR-associated endonuclease Cas3-HD {ECO:0000313|EMBL:AKK01975.1};
GN Name=cas12 {ECO:0000313|EMBL:AKK01975.1};
GN ORFNames=CEPID_00405 {ECO:0000313|EMBL:AKK01975.1};
OS Corynebacterium epidermidicanis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1050174 {ECO:0000313|EMBL:AKK01975.1, ECO:0000313|Proteomes:UP000035368};
RN [1] {ECO:0000313|EMBL:AKK01975.1, ECO:0000313|Proteomes:UP000035368}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45586 {ECO:0000313|EMBL:AKK01975.1,
RC ECO:0000313|Proteomes:UP000035368};
RA Ruckert C., Albersmeier A., Winkler A., Tauch A.;
RT "Complete genome sequence of Corynebacterium epidermidicanis DSM 45586,
RT isolated from the skin of a dog suffering from pruritus.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CP011541; AKK01975.1; -; Genomic_DNA.
DR RefSeq; WP_047239285.1; NZ_CP011541.1.
DR AlphaFoldDB; A0A0G3GN43; -.
DR STRING; 1050174.CEPID_00405; -.
DR KEGG; cei:CEPID_00405; -.
DR PATRIC; fig|1050174.4.peg.86; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000035368; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041372; Cas3_C.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF18395; Cas3_C; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000313|EMBL:AKK01975.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000035368}.
FT DOMAIN 27..233
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 301..506
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 927 AA; 101552 MW; F1126648F1ABA556 CRC64;
MTIVTQADRW LIDRSLQVNA LWAKSGTEEA YLHLPQHLID TACVAEWLWD NWVSAALKTA
LSRTWSLNED HLRRLYVFLA GTHDVGKATV SFQRQAENPP SKSYLLAEVE TAGLSLAWTL
GEGTQKLPHG TASALILRGW LQKWGIGKLQ AVRVSSVVDA HHGFATDPKL LELHQRTIPN
YPEAWASIHA EILDTMAELT DIEDVLDAQL GVGGPYAAAT QLMTGLVIMA DWIASNEDLF
PYRNDQSQVE RVEAAMAAVQ LPSPWQSISA GIDTKLQFQN TFGWPDYFEV RPVQDAAVQI
ARSHESPCLM IIEAPTGEGK TEAGLAAAHV IGEKTGAQGV FVAAPTMSTA NGLFERTTDW
VRRSSQSGEV ASMYLAHSKN QLSEQYQALR FSGIGSDTLD HGSVVANQWL SGRRKGILAD
FVVGTVDQVL MMVLQARFSM LRHVGLAGKV IIIDEVHAYD AYMSQYLYRT LEWLANYGVS
VILMSATLPP AQRKDLAAAY ASQLVTDPDL EKLNTSAYPL ISTVSAAGIA TLPIASRPTD
LEASLTVLDD SLDTLVNQVK ALLVDGGVAL IICNTIARSQ AAFDALSSKF PGDVDLHHSA
FVAAHRSAKE DLLREMLGPQ AHRGSGRPDR KIVVATQVAE QSLDIDADVL VTDIAPIDLV
IQRIGRLHRH RRPDSDRPLL LQEPQVFIRG IQVIDPLPEF DGGAEAVYGR KLLLATMAHL
PAVFRRPDDV AELVRNVYAE NPAIPTGWSE AWREACQKAS AERFSAERRA DAFRFPAPGA
ASEMRYLFDR LHSEPKPGEE EVGNAQVRDA ELTVEAIAIQ KDEYGYRPLG SDEEIQIGSD
VNYGQALALA AHSIRLPARL TRRGSDFDEV IGDLEMQTPG EWSESGILKG QVALIFNTEG
FASAGRFTLR YDLERGLEVV ATEAVQS
//
