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Database: UniProt
Entry: A0A0G3UPT9_9ACTN
LinkDB: A0A0G3UPT9_9ACTN
Original site: A0A0G3UPT9_9ACTN 
ID   A0A0G3UPT9_9ACTN        Unreviewed;       581 AA.
AC   A0A0G3UPT9;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-JUL-2017, entry version 18.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AKL66935.1};
GN   ORFNames=M444_17795 {ECO:0000313|EMBL:AKL66935.1};
OS   Streptomyces sp. Mg1.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=465541 {ECO:0000313|EMBL:AKL66935.1, ECO:0000313|Proteomes:UP000035653};
RN   [1] {ECO:0000313|EMBL:AKL66935.1, ECO:0000313|Proteomes:UP000035653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mg1 {ECO:0000313|EMBL:AKL66935.1,
RC   ECO:0000313|Proteomes:UP000035653};
RX   PubMed=23908282;
RA   Hoefler B.C., Konganti K., Straight P.D.;
RT   "De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using
RT   PacBio Single-Molecule Sequencing.";
RL   Genome Announc. 1:e00535-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP011664; AKL66935.1; -; Genomic_DNA.
DR   EnsemblBacteria; AKL66935; AKL66935; M444_17795.
DR   KEGG; strm:M444_17795; -.
DR   PATRIC; fig|465541.12.peg.3809; -.
DR   KO; K02313; -.
DR   Proteomes; UP000035653; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035653};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035653}.
FT   DOMAIN      274    402       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      488    557       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     282    289       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   581 AA;  64466 MW;  22B31F8B7514658E CRC64;
     MLEKLLGEGQ QGIEPKDKQW VERCQPLALV ADTALLAVPN EWGKRVLEGR LAPLISDALS
     RECGRPIRIA ITVDDSAGEP APPAPSSSQR DAYEPYGGQR PGGPGGHGGG PSDDQLPTAR
     PAYPDYQQQR PEPGAWPRGG QQDDYGWQQP RLGGFPERDP YASPQPGYLQ QSEPSGYDQG
     SYEQQKYEQQ KYEQSGYEPQ QNHQYEQQQY EQPAPRPAPG RPAPSASSGG STSGPLEPTA
     RLNPKYLFDT FVIGASNRFA HAAAVAVAEA PAKAYNPLFI YGESGLGKTH LLHAIGHYAR
     SLYPGTRVRY VSSEEFTNEF INSIRDGKGD AFRKRYREMD ILLVDDIQFL ASKESTQEEF
     FHTFNTLHNA NKQIVLSSDR PPKQLVTLED RLRNRFEWGL ITDVQPPELE TRIAILRKKA
     VQEQLNAPPE VLEFIASRIS RNIRELEGAL IRVTAFASLN RQPVDLGLTE DVLKNLIPGG
     EDSAPEITAS DIMAATADYF GLTVDDLCGS SRSRVLVTAR QIAMYLCREL TDLSLPKIGA
     QFGGRDHTTV MHADRKIRAL MAERRSIYNQ VTELTNRIKN G
//
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