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Database: UniProt
Entry: A0A0G3UY23_9ACTN
LinkDB: A0A0G3UY23_9ACTN
Original site: A0A0G3UY23_9ACTN 
ID   A0A0G3UY23_9ACTN        Unreviewed;       502 AA.
AC   A0A0G3UY23;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=IMCC26256_111 {ECO:0000313|EMBL:AKL72313.1};
OS   Actinobacteria bacterium IMCC26256.
OC   Bacteria; Actinobacteria.
OX   NCBI_TaxID=1650658 {ECO:0000313|EMBL:AKL72313.1, ECO:0000313|Proteomes:UP000035517};
RN   [1] {ECO:0000313|EMBL:AKL72313.1, ECO:0000313|Proteomes:UP000035517}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IMCC26256 {ECO:0000313|EMBL:AKL72313.1,
RC   ECO:0000313|Proteomes:UP000035517};
RA   Kim S.;
RT   "Genome sequencing of freshwater Actinobacteria.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP011489; AKL72313.1; -; Genomic_DNA.
DR   RefSeq; WP_052607517.1; NZ_CP011489.1.
DR   EnsemblBacteria; AKL72313; AKL72313; IMCC26256_111.
DR   KEGG; abai:IMCC26256_111; -.
DR   PATRIC; fig|1650658.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000035517; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035517};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035517}.
FT   DOMAIN      193    321       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      406    475       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     201    208       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   502 AA;  55707 MW;  74A4254668746C46 CRC64;
     MTQAEELWAI GAAAVRAELK DATWNAWFRE VRAVSFDGEV LTLSVPSGVA REKLRSNYTG
     LLTSLLQEAT GEEIDVELIV STPDRIEQSI TLDENLSLHY ETSTRGPARS NPLGDNQGRN
     QQQSGALSGS SGSGSSGSGS SGSGSPETGG GGENQAQWAS LNPRYTFEHF VIGASNRFAH
     AAALSVAENP ARSYNPLFIY GPAGLGKTHL LHAIGNYVRD VHKLQRVRYV STETLMNEFV
     DSIRSNTSNA FRRRYREVEV LLVDDIQFLE RSQQLQEEFF HTFNSLHAAG NQIVISSDRP
     PKQIPRLEDR LRTRLEWGLI TDVSPPEFET RLAILRMKAE SENLAGIPSE VLDFIASNIS
     DNVRELEGAL IRVAAYSSLN RSPLTEEIAK QVLHDILPPT KPRVITPALI LDETAKMFGF
     PVEDLCGRSR RRPLVMARQI GMYVFREMTD YSYPRIAEEF GGRDHTTVIH AVEKIKGLLT
     ERHTVFDQVN ELMGRIRLGT GG
//
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