ID   A0A0G4EP03_VITBC        Unreviewed;       912 AA.
AC   A0A0G4EP03;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN   ORFNames=Vbra_2889 {ECO:0000313|EMBL:CEL99181.1};
OS   Vitrella brassicaformis (strain CCMP3155).
OC   Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX   NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEL99181.1, ECO:0000313|Proteomes:UP000041254};
RN   [1] {ECO:0000313|EMBL:CEL99181.1, ECO:0000313|Proteomes:UP000041254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhu J., Qi W., Song R.;
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CDMY01000275; CEL99181.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G4EP03; -.
DR   STRING; 1169540.A0A0G4EP03; -.
DR   VEuPathDB; CryptoDB:Vbra_2889; -.
DR   InParanoid; A0A0G4EP03; -.
DR   OrthoDB; 276868at2759; -.
DR   Proteomes; UP000041254; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF7; SD02261P; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        67..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        416..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        445..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        486..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        550..571
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          450..575
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   REGION          303..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          728..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          809..828
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..354
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..667
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  101333 MW;  5AA68EC4FBC95122 CRC64;
     MPTGAAGGVT MLTNISRFVT SLRRRGDGDG GGGRRMRRQS ARMSLSDQLF LNPFEKWRRH
     GKFPWKFFIH CLLAILTALQ VVVFITQETG HAKMTLRHFY TIFLGEDVTG AFGSRTFTIS
     NEKDFKDTLY STIEHYFHIN SQSMSIDKYA YPNEHPTAIV EVTWRDGVTN EFPLDAKFRK
     DHKYMDIIDR VQDLYEVRIR LVVLELFKGP LWTSCFEWHL SPTFNYQMTG QIEVLLGWNI
     YECSAADMRH PAPYHKLNIR GKLKFPYSFL HAVVAVLAAL SFILAWKAIR DSVLVLRKIR
     QSTRSPAPPS TYQITPLRHV SRPEEADDLG PPGQDAEEAS RGGLHHDSTE DRPPPPNRLQ
     RTGANAMIGG SFADGRVEEL LCRSMSVRSM DTAYFLDQHD VITWEHLTWR EKLSFFNLWF
     CITIVGNLIQ FIATITCFLP GGSVTGRLVC LGVACFFAWL NLLRYLEYFS TYYLLIRTLQ
     MGVPRVGEFL VGVVPVFFGF AVMGVCLFWP TDNFSTLTQA SMSLFAVLNG DMIHDTFANL
     GDISPIFSQI YLYSFLCLFI YVVLNVFISI IEDSFFSEKI RDMELSAAPG GTQPGYASIG
     SVHPPVMLEP RGGNGGPMGG ALVAGEDNVR FRDRRQEGPD VTLTAGPHYQ PSAPPGSPYP
     RGPPSHPSTE TPRAERTDDR RSAPLVYPPG GGYSDSSLSA PLLQERQQQR SGRVVNPKIE
     ALIKTAEMVQ EQEGRDGSPS ARSAAGSAHG GLGRVMPTPQ SAPRRPPPSP AQATRKGAPE
     ALLPEEEPRV GDERRGIAAS MEIMGRQQAQ QAAAAGGGAG QGEGGSGQVR RGVQYLHTFS
     QTAQSKGYGL RPGVKMDIEG WSDAMHELLA ALPSLIPPTN AFQSYMATAL LRQKVRDARR
     MLDEFLKQAP LH
//