ID A0A0G4EPX3_VITBC Unreviewed; 779 AA.
AC A0A0G4EPX3;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Vbra_20695 {ECO:0000313|EMBL:CEL99643.1};
OS Vitrella brassicaformis (strain CCMP3155).
OC Eukaryota; Sar; Alveolata; Colpodellida; Vitrellaceae; Vitrella.
OX NCBI_TaxID=1169540 {ECO:0000313|EMBL:CEL99643.1, ECO:0000313|Proteomes:UP000041254};
RN [1] {ECO:0000313|EMBL:CEL99643.1, ECO:0000313|Proteomes:UP000041254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhu J., Qi W., Song R.;
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CDMY01000285; CEL99643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4EPX3; -.
DR STRING; 1169540.A0A0G4EPX3; -.
DR VEuPathDB; CryptoDB:Vbra_20695; -.
DR InParanoid; A0A0G4EPX3; -.
DR OrthoDB; 248389at2759; -.
DR PhylomeDB; A0A0G4EPX3; -.
DR Proteomes; UP000041254; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000041254};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..189
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 277..343
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 471..532
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 343..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..779
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 84479 MW; 887C2267B6285F44 CRC64;
MAILNAGVDI FLICVLSCFS ALFSGLTLGL MSLDKVQLQI LIDVGKQDKA DLNAKRQAWY
ARRILPVRRD GNLLLCTLLL GNVAVNSCLS ILMAEQGFIL GLVLSTTVIV LFGEIAPQAA
CSRYGLAVGA YTVWIVWIFV FLMYPIAKPI ALLLDWILGE EMGSVLNRKQ LKALLAHHEK
QAHVITSNEA QILEGALDFS GRSVKEAMTP IDRVFGVDVN DTLNFDLASA ILESGFSRIP
VFDRTKPCCI VGLLLVKDMA IIDPASEVPI VNVIHLFGRE IYAVDSDTSL LNLLTDFKKG
KTHLAVVREV VTETDGDPYW VHVGIITLED IIEEIIQDEI KDEHDAEVED DKESEGGGGI
HKGGSTESLD STHKGGGQHV ALPIDKGLKR RSLSSSSLAA YKFVQQHAAG APVSGGEMDR
YSMMLVGRLK LFDRKRGIQP LSEPEALAVA SFLSATQLPF SATAGYIHGH VLDQLVKKLL
VIKPPKGTVL YQKGEKSDTA YLILQGKVKV QVGRDAFECV LGPWCTLGMR ALKPPQLVTD
TTAASSSSVV PQPPPSSPSH PPFDPSGHRS NISDPQISLH TPHTPHPHTD ASLSPPMPAA
MPDKDRARMR LFGGFRKDQQ QQQHGTVPAS PPMQRAVTAL KASNKVIQVS ADKSVELSGW
EVTFVPDFTA VTVDDGARLL VIRRSDYLHA FKATLLNTPM GVSLPPSPAH TPVNVASSPT
TMTVLPEGQV MAPPPPPQPS NHHSHPEEQV DEPEGDRDVV GEVNIHIPDE LHEEDLGLS
//
