ID A0A0G4IRL6_PLABS Unreviewed; 819 AA.
AC A0A0G4IRL6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PBRA_006133 {ECO:0000313|EMBL:CEO98018.1}, PLBR_LOCUS3373
GN {ECO:0000313|EMBL:SPQ96158.1};
OS Plasmodiophora brassicae (Clubroot disease agent).
OG Mitochondrion {ECO:0000313|EMBL:SPQ96158.1}.
OC Eukaryota; Sar; Rhizaria; Endomyxa; Phytomyxea; Plasmodiophorida;
OC Plasmodiophoridae; Plasmodiophora.
OX NCBI_TaxID=37360 {ECO:0000313|EMBL:CEO98018.1, ECO:0000313|Proteomes:UP000039324};
RN [1] {ECO:0000313|EMBL:CEO98018.1, ECO:0000313|Proteomes:UP000039324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3 {ECO:0000313|EMBL:CEO98018.1};
RA Chooi Y.-H.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPQ96158.1, ECO:0000313|Proteomes:UP000290189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Fogelqvist J.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; CDSF01000082; CEO98018.1; -; Genomic_DNA.
DR EMBL; OVEO01000005; SPQ96158.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4IRL6; -.
DR STRING; 37360.A0A0G4IRL6; -.
DR EnsemblProtists; CEO98018; CEO98018; PBRA_006133.
DR OMA; GKGFFAW; -.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000039324; Unassembled WGS sequence.
DR Proteomes; UP000290189; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000313|EMBL:SPQ96158.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000039324};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..182
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 207..367
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 378..651
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 785..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 261..319
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 785..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 92826 MW; 42F9AAB55765920A CRC64;
MADNNNDGGQ GAIDMAQQAD DTSLVSFVSS IWTNLIIMVV VFLVFAVASK KIGWVYRPRV
VCPNSSERRA KPPNFNMLNL AWVYDLMRMP WEDIVPIVGV DAALYLRFFH VGIKFFAVTT
VLGCTLLIPV NITNYDQGER SANFKMADLT IQNVAEGSGY LWSHVFVAYV SAVYLLYLLY
KEYVAYVDMR HRYFLSNREE ALRVEQMSVL LVDIPDDIKT DDDLDRYIRS RFDNGDVVAN
AILVKRSEDL AKLHDERADV VAQIEDAVAK LCRKADERKE EGTKTKRLKI SEEELNDSIA
KLRVKLDDLN EKIRSKQAES HDAYRTGFAT FKTFAATATA SQLPWTHEVL SMEAHVAPEP
RDLYWPNLHL TRRARVIRQL VAAALFLLLF TTYTVPVAFI TSITSLENLQ AQFPMLAGYL
EANPAVRGQL QGFLPGLAMI IFMAVLPPLL RFFATIKGVV SHSAIDRNVF IYYFYFQFVH
FFLFACLTQG VMGLVKDKSL SDMNLDFLLQ SLAKAVSTQA NPFLIQIMTR SFTTVPLELL
VISKLLLGSL KMTRARTARD VRDVTYAGTF AYGEYYPVYL MLFLYGIIYA PIAPLILPFC
LALCVTCAVV YRYMFCFVYA HESESGGALF PHVFRRVVFG LGFAQVVLIA LLIGKNCPQM
CVAVLPLLGF TTWYYFFMER NFGSRAERLS LEEIRALDRY LVQASRRITL GDATALDHIR
RPGHSAYKPV WEVEHDVDID RIKDVAVRAH PLVVQMHHDP KVLHRLVSRE FELLPGASNV
RLSRIDETED SERAGVDERR SSPPRLAWSS DNIAGEAPV
//
