ID A0A0G4ISM2_PLABS Unreviewed; 860 AA.
AC A0A0G4ISM2;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PBRA_006336 {ECO:0000313|EMBL:CEO98222.1}, PLBR_LOCUS2420
GN {ECO:0000313|EMBL:SPQ95205.1};
OS Plasmodiophora brassicae (Clubroot disease agent).
OG Mitochondrion {ECO:0000313|EMBL:SPQ95205.1}.
OC Eukaryota; Sar; Rhizaria; Endomyxa; Phytomyxea; Plasmodiophorida;
OC Plasmodiophoridae; Plasmodiophora.
OX NCBI_TaxID=37360 {ECO:0000313|EMBL:CEO98222.1, ECO:0000313|Proteomes:UP000039324};
RN [1] {ECO:0000313|EMBL:CEO98222.1, ECO:0000313|Proteomes:UP000039324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3 {ECO:0000313|EMBL:CEO98222.1};
RA Chooi Y.-H.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPQ95205.1, ECO:0000313|Proteomes:UP000290189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Fogelqvist J.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CDSF01000083; CEO98222.1; -; Genomic_DNA.
DR EMBL; OVEO01000003; SPQ95205.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4ISM2; -.
DR STRING; 37360.A0A0G4ISM2; -.
DR EnsemblProtists; CEO98222; CEO98222; PBRA_006336.
DR OMA; RMRIIGQ; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000039324; Unassembled WGS sequence.
DR Proteomes; UP000290189; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Mitochondrion {ECO:0000313|EMBL:SPQ95205.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000039324}.
FT DOMAIN 217..343
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 659..806
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 381..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 94336 MW; B6B5472FCABD8CE7 CRC64;
MHALSSAAVD RLSGAQVIVD LRTALKELIE NALDAGATRI DVRLKGGGAD EINVSDDGVG
IINEDRPNLV LRHHTSKISR FSDLESVKTF GFRGEALAAL CALSSSFEVT TRTSDDTVGA
LLVYEADGTL KCQSHASRSV GTTVSVKGLF AALPVRRHAL LKTIKKQLAS AVSSVQAYAL
LTGLPLGEGQ APPRISLWSD ARRVINTTVS GGSAAIVSAL FGAEQAAQVQ YVDIALSETV
SVHGWLSKPD HSGSGSSGRS APDRQFVGIN QRPVDLPSFL RVLNKSFRSV ITCKSRYPFA
VLNLSLPTDA YDINVTPDKR LCLLHNEAEL LEQFEEFASK LYVAPDAIEF EHVANRENES
LLSSPVPGKV DESPVDRLIA SQELSQRPDE NPAARSRESS ALAASPEYLE LPQRSKPVQE
EHADVSALQQ SSQSPRSDIG TGTRLRMSPP EPNEDVGHME VDGFRAGPPV IVMSCSDDGS
TSDHDASDSI GRQSGLEKVS APSPTHRELE HPSRRIRDRS QSPNKNRGDV NAMEFPPNKI
PRRRFTPVPV QEIHVEKVVD FSADALRSSW ETDRRSEANP ELDAAREDES LTIHFDEREV
GVLYRKMTAD VTRELSSQHN VGDAAEFLDV VHDHSAVNGD DESTIRRRIQ KDDFLRMGVI
GQFNLGFIIV RLDDDLFIID QHASNEKYNF ETLMATSKLT SQRLICPRIL ETCAATELTI
IENISIFKQS GFDIEADLDA DPGRRLKLLA IPVSQQVAFG LDDIFELAAR ISSDDLAGAT
SVPLARLSSL MATRACRMSV MIGDPLNHTQ MCKIVTDLAT IHQPWNCPHG RPTMRHLFNL
AALRMQQRRS WSNRNPLQAE
//
