ID   A0A0G4L3K7_9PEZI        Unreviewed;       865 AA.
AC   A0A0G4L3K7;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE            EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE   AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN   ORFNames=BN1708_002853 {ECO:0000313|EMBL:CRK16594.1};
OS   Verticillium longisporum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=100787 {ECO:0000313|EMBL:CRK16594.1, ECO:0000313|Proteomes:UP000044602};
RN   [1] {ECO:0000313|EMBL:CRK16594.1, ECO:0000313|Proteomes:UP000044602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VL1 {ECO:0000313|EMBL:CRK16594.1};
RA   Wang D.B., Wang M.;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC         tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC         COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001372};
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DR   EMBL; CVQH01007779; CRK16594.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G4L3K7; -.
DR   STRING; 100787.A0A0G4L3K7; -.
DR   OrthoDB; 5472610at2759; -.
DR   Proteomes; UP000044602; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00395; leuS_arch; 1.
DR   PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF00133; tRNA-synt_1; 2.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE   4: Predicted;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000044602}.
FT   DOMAIN          68..132
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          218..794
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
SQ   SEQUENCE   865 AA;  97698 MW;  B3FC7AD653A5B247 CRC64;
     MATADPAKEM ENLQISKTKE LKGTEKRDTL IAIEKKYQQQ WADSKIFEID APSIEEYPLD
     SISAEELREK HPKWFGCIAY SYVNGKLHAG HVFSQSKVEF GAGTARMSGK RALFPMGWHA
     TGMPIPAVAD KLKYEIEKFG RGFEGYKEEE EEAEEPAPVT TVKRDDVTKF TTKKSKATAK
     TAKAKYQFQI MQSMGIPTEQ IHLFADAQYW LTFFPHLGQQ DVTSLGFRVD WRRSFITTDI
     NPYYDAFIRW QMNRLKELGK IKFGKRYTVY SIKDGQPCMD HDRSEGEGVG PQEYTGLKMK
     VLGWAPKAKE ALESKLPADA SVYLIPATLR PETMYGQCAL FVSPKINYGI FKASDKEYYL
     VTHRASRNMA YQGVFAKEDE IEHLTDISGA DVVGSLVNAP LSVHSEGVRV LPMDTILPSK
     GTGVVSCVPS DSPADWITLM DLRKKAAYYG IEQAWAELDV VPVIDTPMGD LIAKTLCEQL
     KIGSPKDTVQ LEKAKDTAYT EGRSFYKGTM KVGDYKGEAV ETAKPKVRKQ LIDGGLAFVY
     SEPERKVISR SADECIVALM DQWYLDYGEP TWRDQALEWV ANADGKGLET FGNETRNAFE
     GVLNWLNQWA CARSYGLGTK LPFDPKFVVE SLSDSTIYMA YYTICHFLHA DIYGKEPGTL
     NVSADQMTDD VWDAIFCRRE LDDEVIKASG ISKEALQTMK RSFEYFYPLD LRSSGKDLIG
     NHLTFFLYIH IAIFPKKYWP RAIRTNGHLL LNGEKMSKST GNFMTLEDMA KKYGADASRI
     GLADAGDTMG DSNFEEDVAN QAILRLHTAR DWCEETVKNK SELRTGEYNY FDEIFNNDLN
     ALAKETIAQY KETSYKLALK AGFYE
//