ID   A0A0G4LJB1_9PEZI        Unreviewed;      3249 AA.
AC   A0A0G4LJB1;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN   ORFNames=BN1708_013311 {ECO:0000313|EMBL:CRK22121.1};
OS   Verticillium longisporum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=100787 {ECO:0000313|EMBL:CRK22121.1, ECO:0000313|Proteomes:UP000044602};
RN   [1] {ECO:0000313|EMBL:CRK22121.1, ECO:0000313|Proteomes:UP000044602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VL1 {ECO:0000313|EMBL:CRK22121.1};
RA   Wang D.B., Wang M.;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CVQH01013558; CRK22121.1; -; Genomic_DNA.
DR   STRING; 100787.A0A0G4LJB1; -.
DR   OrthoDB; 1356198at2759; -.
DR   Proteomes; UP000044602; Unassembled WGS sequence.
DR   GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProt.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 3.40.50.12390; -; 2.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000044602}.
FT   DOMAIN          1981..2112
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          413..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3249 AA;  362009 MW;  DE211A2C90B74E14 CRC64;
     MGIPAAFRWL SNKYPKIISP VVEDQPLQME DGTTIPVDTT GPNPNGEELD NLYLDMNGIV
     HPCSHPEDRP APKDEEEMML EVFKYTDRVV NMVRPRKLLM IAVDGVAPRA KMNQQRSRRF
     RSAQEAQEKE VDKQELLKLL KQQNGGILPP ETLESMNKKA FDSNSITPGT PFMDTLATSL
     RYWCAYKLNT DPAWARLKII ISDATVPGEG EHKIMNYVRS QRGSPDYDPN TRHVIYGLDA
     DLIMLGLATH EPHFRVLRED VFAQDAKAKM CKICGQKGHD ARVCKGEAKD KDGEYDEQDK
     AVDLKPFIWL HVSIFREYLA IELDVPDLPF RFDLERAIDD WVFMCCFVGN DFLPHLPALE
     IRENGIDALT TIWKENLPRM GGYVTKDGHI DLKRVQLIMD GLAKQEDAIF RRRKEQEDRR
     EANAKRRKLQ DERSGRGGRT DASGRGRGKP PLDNASSGLA LFPVSGFPNA DPSAVTHDMV
     VGRSSNANIN ANAANKNAAN VIRDRIQALG AQGKSTNGDA TTHPKVEVPA VPEDGAAAAS
     SVVKRKADVL DGPSQLTPNI GPSAAEEAAI DHVRMWEEGY ADRYYEQKFH VDRNDVAFRH
     KVAQAYVEGL CWVLLYYYQG CPSWDWYYPY HYAPFAADFA DLDKIEISFE KGRISKPFEQ
     LMSVMPAASR RALPEVFHDL MLNEDSEVID FYPQEFEIDL NGKKFAWQGV ALLPFIDMPR
     LLAAVEKKYP LLSPEDAARN GIGRDVLLLS DAHHELYEDI TSHFYSKKQG APTFGLNPRT
     SDGMTGQVEK IADYLPHGSL EYPLDRKSMP SLDYDRSLST RVTLVKISAT NIAAILDSLI
     TLLEELGRGY KGFSSHPSHV VSSEVYVLAL ASDCCAAHWE AVRSNSLRQL VKQTNTRRGS
     LQVVPTPLDD SLVSRLLNVL RNLLDPTPDG FILPAHTILG RCPRHSERAA RLDTGADNLS
     QDDVLATDKY DSTISPVSVE SHAKTLVEYL TASSWTSVFD HLRKVVYTIR TTGVAQQQPS
     QPPPVGEDDR ANLVALRLIS FYWVDSQKLG QVIQEICSSY LHLRRPFQTA IAAVLPLLVV
     SWLERHPHEF VQLHTLHKRL DGGADTLFDM TQAIVDNGRK KGMMFAMQIT LLLLLPDVFE
     VASNLREAKS SSMAKKTAFL DGLRKSLRNK NEAAAYCLVL LLRAARHFDA EDDTAIVSFA
     LDVQDEVKDA VFRRSAPNAD GSHFEQDLLS AAFVGLAQLN PESGLDALAE TCLAMGTPTS
     FRRAVVQGCS YLARQNDSHR YEALFGTATP YMLSQLKDIA GLLSDNSALD ITVQALDHPK
     ALMACNVLDF LEASPQSLLE VEERKPGSTA PAHSMFEAFL CLVLSWDPGV RAHATRVAKR
     LFVDRAVIED LRSQGTLDSS ALKISFWRRS CRLIVSLCDQ VMAGGGSIAV RAIYDYLAAR
     VVLLNSLREL SEVPGDIPEL PTAASKTETT LLVALCSADV ETCRLVTSLV ATALEANEAA
     EASPEAAKVL APLLRNSDIF RELGSGSFRF TGLVAFQKRM RGLLRRLQYP TIGILAAWEH
     AFERWLLLSR EVSSTPADAI EDKVFSEWRN HSGFLASLGG ICVANPAIIL EEPTLSSARW
     IDQLPNDNHE EPLLDRYLRL SIQLLGCTNI RVREATREVL SSDISPTLYQ PMFRALESEL
     EVLFTGALAP SDQAQDIEVA FAEQAISLLK ALVERLDSPS DLGAASSVHL GALTLSFTKF
     MDSMADSTST LRVKIKVCQL CETVNRRKEH LNLRDDVRIR NHLLEYIFGW IARPRTPRVD
     PHQGVMLGRP DDAQRMQKDL DRACLRSLAE LTFRLPLQPG EGQTDAGASE LKAQMFHTYF
     NRFLSLLNHD SSEINKGDIM PTGVGRDDTA SASELAITIL SNLLSANIDV GLKHSLNIGY
     HDNVDIRTAF VKVLCNILIQ GTEFSNLTDS AVNEKYNELL DLLTKDMTLV AAMSIVCPSH
     EVDELTISLL TIFEHRGRTF ELIETLIKQE IEQTDNESEI LRRTCVATKM LSVYAKWKGQ
     AYLKATLQKV VERLVLTSKD LGLELDPARV TSNDELQKNA LQLRIVAKVF IDDICASSSS
     VPSSFRQICS IVPPDSLDHE SSIESFDFGS CVALHRFLYD HWDHIRQKLV GHERRDYVRS
     PAEISRVRSP VLEPLRNLIT NLGPPPLAVT WNRPQVSTNT PPSYSMFQDF MLRNAFRGTE
     SFLTARAVYD GGESKDGLSI ICIILRHMDS ESIDYETLIF CYLKIASRLW HKPFGLLIDA
     TCYNGQNEPQ DDLLRKLDSL TPVELNRNLT RVYVYNMNSA FRKCFRRILR VSAKSESSVF
     HPKNVEYHLI GSLQDLQAHF HLSQLHLPKE TISVVTDTRY VFQPITRLSK TKGKIEVIIK
     VGSQFVQVTT TKKQEVFPGY RLSTTVNDIF RLGEVDEAPT SIQTEDDSAF GLRADSGRIV
     MYFTSPKKVD VLQTIRGAKA KYSKDSRSHK AYERLIRPQD VPGTLLNLAL TNLSSVDDVL
     RLASYNLLGS LCKAFRFSAA SKMMCLIDVS VPTSASHFII AISEQLAQTE PQLTFDFLTE
     FFVGWESFSD DQKPISLAYM SPWLPGLRTA ILANEADGDR GKEKIASLFR KLIDLAVADH
     FLAYTLEQVV WPAISQDETI LDLFLEELTK AALSLNLADE SLDALSSIVA GIGTITLRAR
     VISRLRKALN RTSLRPTKAL PDNVVWAEIC VLLHFCLSLS FDNGVQAQLF LPEIFHIVTM
     LANTGSVEIR ILVHRLLVNT VHAACTSFLL EDLRLNKLRS SLDLINDSRG EVFSASSSTL
     RDTTSITTTQ DTGPALAATE SLAALLFEIC SLAAPSVDIS NAWRSRWMSL VASTAFQNNP
     AVQPRAFTVM GCLAREEVDD DLLYQVLVAL RNSVGRLEDE SNNDMFVSIV TSLSRMMSKL
     PSASRYGLQL FWLAISLLRL VPAALFNCTA QFLEAVLSNI NTVGGLRGEN MAALLIQGRV
     QLEEAAVLLD DAYDVHFSRE SFHFAVCACL ARGLVDTTTR QGTMRVLSSF LEMAGSFSND
     SDGPIRSSLD SPYMALVLAR VAGHQELKDI LWSSGVNPSL VGMVASTRQL QDISRANDQD
     LLLNTAIELV DFQYLEDAIQ DRTLRWLALL AKARPTVVLH LCGPLATILN DTLSHCQNST
     TLEAAHLLLH CLALDPRLNQ ALDTPVRLED VLDDLGFSGL WRSCSMDSAH EQDRKYFTLT
     ERLIELIII
//