ID A0A0G4M2E6_9PEZI Unreviewed; 1507 AA.
AC A0A0G4M2E6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
DE AltName: Full=Vacuolar carboxypeptidase Sorting receptor VPS10 {ECO:0000256|ARBA:ARBA00032705, ECO:0000256|ARBA:ARBA00032910};
GN ORFNames=BN1708_015056 {ECO:0000313|EMBL:CRK28010.1};
OS Verticillium longisporum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=100787 {ECO:0000313|EMBL:CRK28010.1, ECO:0000313|Proteomes:UP000044602};
RN [1] {ECO:0000313|EMBL:CRK28010.1, ECO:0000313|Proteomes:UP000044602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VL1 {ECO:0000313|EMBL:CRK28010.1};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
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DR EMBL; CVQH01020596; CRK28010.1; -; Genomic_DNA.
DR STRING; 100787.A0A0G4M2E6; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000044602; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000044602};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1507
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002566806"
FT TRANSMEM 1378..1399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1428..1449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..684
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 733..1367
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 1486..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1493..1507
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1507 AA; 168537 MW; 04514D1706E21A99 CRC64;
MRIRGRGAAS WRTLLFVLSW TTTALAKDDG PTIKVSKFKH PPLNMNYFED SDVVLFHDMS
ENNIYRSDDA GVSWGKVAGV PDGVAYTLAM HGFDNSRAFI ITDRREHFKT TDRGKSWEKF
DSGAQTSRYR DQILSFHAGD PDRVIFNGMD CAGIFCNEVA TYTTNNFKEA KTLRGSTEGC
WWAKSSDLFT TGKDDLDRQR VLCIGADSIS PFKEDQRLFI SDNFFEKIDG KVQQFEPNLD
TNHGIQGVVN LAVVKKYLLV ATTSINTDEM SLFVTDDTLK WHRAMFPAAH GHKVNQGAYT
VLEGTNYSIQ VDVMNTRPSN PMGVMFTSNS NGTYFVENLE HTNRNERGNV DFEKISGIQG
IFLVNTVKNW EDVEKHGGSR KEVVTQITFD DGRTFHDIKA GDDRVHLHSV THLDNVGRVF
SSPAPGLVMG VGNTGSSLND FEEGNLFVSD DAGASWKKAL DGPHKYEFGD QGSLLVAVKD
SKKDDVSEVS YSLDHGLNWK TAALPDSLKL KPEIITTTQD STSLKFILVG SSGGDNYHVV
ALDFGGLQEK TCEDNDMEDW SARVDKDGKA ICVMGHKQTY RRRKKDADCF LKKEFKDPVP
KTEDCECSDA DFECDYNFIR KDGECEKAGP IVAPDEACKS AGPDTTFKGS SGWRLIPGNT
CKRKDGSQKD DPVDRKCSDV VNSPAPPASG DITATQHIFK DTKLNDFEKI YLERGDSSSD
SDETVIARAV EYENDGSMRV EQRVYRTRDH GKKWDEILEK EEIRGIYPHQ YFKDAVFFTT
KSRKVWYTID RAEHFHEFEA PSDPGSGNPL SFHPDKKDWL IWVGQKCEKV DGKEQCFKEA
SISRDRGDNW RTALRYVQKC EFTGRSTYKF RDMRQIVCLT HKREDNEPDN PKVIVSSNDF
FEEDKQVRES NVKDFATMAE FIVVAAEDKE QKGLRALASL DGETYAAAHF PYNFEVSHQN
AYTVLDSSTH AVNLFVATQL EKNQRQGSVL KSNSNGTSYV MSAPKVNCDN NYFVDFEKII
GLEGVVLINS VTGKDKKGNK ILRTEISHND GSQWAYLPPP KVDVNGKAYG CSSTYGDEKC
ALHLHHYTER LDKKKTFSAA SVAGLMFGYG NIGSSLGPIE EADTFMTTDA GITWKSVKKG
AWTWQYGDQG SIVVLVPRST EDKDAKTKSI SYTTNEGKDW KDFEFSKEEV TILDITSTRT
GSSRNFLLWC SSSDGKTLSV NLDFTGLTDR PCVNPESGDS DYYVWSPTHP LQDNECLFGH
VSKYLRKKTD RNCYNDHRIE HLYAISNCTC TRADYECDYN FELDPHKQCS LVPGKKPLSA
EQYCKENPDA VSYYEPTGYR RIPLTTCVGG TELDKISEAH PCKGKEEEFE KLRGTSGVAI
FFAIVIPIGI AAAVGWWVWR NYGSQFGQIR LGESSGFDND APWVKYPVIA VSAAVAVVAA
LPLLGSALWR TASSAYERVS GGGGSWLNGG GQRRFTTRDS FARGRGDYAS VDDDEGELLG
DDSDEEV
//
