ID A0A0G4MK72_9PEZI Unreviewed; 1159 AA.
AC A0A0G4MK72;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
DE Flags: Fragment;
GN ORFNames=BN1708_006409 {ECO:0000313|EMBL:CRK34574.1};
OS Verticillium longisporum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=100787 {ECO:0000313|EMBL:CRK34574.1, ECO:0000313|Proteomes:UP000044602};
RN [1] {ECO:0000313|EMBL:CRK34574.1, ECO:0000313|Proteomes:UP000044602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VL1 {ECO:0000313|EMBL:CRK34574.1};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-
CC O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+);
CC Xref=Rhea:RHEA:17377, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527,
CC Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:13546, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211,
CC ChEBI:CHEBI:137321; EC=2.4.1.109;
CC Evidence={ECO:0000256|ARBA:ARBA00034032};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] =
CC 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate +
CC H(+); Xref=Rhea:RHEA:53396, Rhea:RHEA-COMP:9517, Rhea:RHEA-COMP:9527,
CC Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13547, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30013, ChEBI:CHEBI:57683, ChEBI:CHEBI:58211,
CC ChEBI:CHEBI:137323; EC=2.4.1.109;
CC Evidence={ECO:0000256|ARBA:ARBA00033990};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 39 family.
CC {ECO:0000256|ARBA:ARBA00007222}.
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DR EMBL; CVQH01023083; CRK34574.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4MK72; -.
DR STRING; 100787.A0A0G4MK72; -.
DR OrthoDB; 5489060at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000044602; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.80.10.50; -; 2.
DR InterPro; IPR027005; GlyclTrfase_39-like.
DR InterPro; IPR003342; Glyco_trans_39/83.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR032421; PMT_4TMC.
DR PANTHER; PTHR10050; DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE; 1.
DR PANTHER; PTHR10050:SF46; PROTEIN O-MANNOSYL-TRANSFERASE 2; 1.
DR Pfam; PF02815; MIR; 2.
DR Pfam; PF02366; PMT; 2.
DR Pfam; PF16192; PMT_4TMC; 2.
DR SMART; SM00472; MIR; 6.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 6.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000044602};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1055..1076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 335..389
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 401..457
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 465..523
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 789..843
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 855..911
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 919..977
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1159
FT /evidence="ECO:0000313|EMBL:CRK34574.1"
SQ SEQUENCE 1159 AA; 131436 MW; 3588710FAB4352EC CRC64;
MASSKPVVAS GADVGDGVRR RPIAAGQSVP VTAKPEVDNK KQIAKKQPTA LDFLDEWEFI
LAPLIFTAVA VFTRLYKIGL SNIVTWDEAH FGKFGSHYIK HEYYFDVHPP LGKMLVGLSG
VLAGYNGSFE FKSGEKYPAD VDYTFMRAFN AFFGILCIPL AYYTARELKL RRPAVWLVTL
MVLCENSYTT ISRFILLDSM LLCGTVLTVF CWSKFHNQRH NSFEPEWFLW LFLTGLSIGC
VCSVKLVGLF VTSLVGLYTI EDLWNKFGDT KMPFTTLGAH VISRVVGLIV IPLLVYMLSF
AAHFAILDHS GPGDAQMSSL FQANLKGTQV GKDSPLEIAY GSRATIKNMG YGGGLLHSHV
QTYPEGSNQQ QVTCYHHKDT NNDWFFYPNR DEEPYDAEAE PRYIADGTTI RLIHAQTGRN
LHSHEIAAPM TKSDKEVSCY GNLTVGDAKD HWKIEVVRDA ASRDRSRVRT LTTAFRLKHP
VLGCYLRAGN KNLPQWGFKQ IEVTCTKTNN PRDTYTHWNV EAHWNDKIPK SDPGVYKSPF
IHDFFHLNVA MMTSNNALVP DPDKQDDLAS HWWQWPILDV GLRMCSWDDS VVKYFLLGNP
FVYWGTTLGL GVFGLVIAWY VLRWQRGFGD LNYKEVDQIH YAGVYPVIDR LNMASSKPVV
ASGADVGDGV RRRPIAAGQS VPVTAKPEVD NKKQLAKKQP TALDFLDEWE FILAPLLFTA
VAIFTRLYKI GLSNIVTWDE AHFGKFGSHY IKHEYYFDVH PPLGKMLVGL SGVLAGYNGS
FEFKSGENPL EIAYGSRATI KNMGYGGGLL HSHVQTYPEG SNQQQVTCYH HKDTNNDWFF
YPNRDEEPYD AEAEPRYIAD GTTIRLIHAQ TGRNLHSHEI AAPMTKSDKE VSCYGNLTVG
DAKDHWKIEV VRDAASRDRS RVRTLTTAFR LKHPVLGCYL RAGNKNLPQW GFKQIEVTCT
KTNNPRDTYT HWNVEAHWND KLPKSDPGVY KSPFIHDFFH LNVAMMTSNN ALVPDPDKQD
DLASHWWQWP ILDVGLRMCS WDDSVVKYFL LGNPFVYWGT TLGLGVFGLV IAWYVLRWQR
GFGDLNYKEV DQIHYAGVYP VIGWVLHYLP FYAIYGVLYL VIIGLYINFI PICFGMVGSN
KQFSYLRWSD KWRISDPIV
//