ID A0A0G4N6X1_9PEZI Unreviewed; 922 AA.
AC A0A0G4N6X1;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=BN1708_008702 {ECO:0000313|EMBL:CRK42237.1};
OS Verticillium longisporum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=100787 {ECO:0000313|EMBL:CRK42237.1, ECO:0000313|Proteomes:UP000044602};
RN [1] {ECO:0000313|EMBL:CRK42237.1, ECO:0000313|Proteomes:UP000044602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VL1 {ECO:0000313|EMBL:CRK42237.1};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CVQH01027416; CRK42237.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G4N6X1; -.
DR STRING; 100787.A0A0G4N6X1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000044602; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000044602}.
FT DOMAIN 734..750
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 922 AA; 103907 MW; CABC832AB6447803 CRC64;
MSSRPELKVD DEHGFIRYFK SLPEVHEDTI RIFDRGDWYT AHGEDANFIA RTVYKTTSVV
RQLGRDDKSG LPSVTMTVTV FRQFLREALY KLSKRVEIYQ STSGRMNWKV VKQASPGNLQ
DVEEELGGQF EAAPMILAVK ITAKASEARS VGVCFADASV RELGVSEFLD NDLYSNFEAL
LIQLGVRECL IQADKAEKDK RDPELTKLRQ IIDNCGVAVS ERSAVEFGTK DIEQDLARLL
KDERAVTLLP QTELKLSMGS AAALIKYLGV LHDPSNFGQY QLYQHDLAQF MKLDAAALKA
LNLMPGPRDG AKSMSVYGLL NHCKTPNGSR LLSQWLKQPL MSKQDIEKRQ QLVEAFVSDT
ELRQTMQEEH LRSVPDLYRL AKRFQRKKAN LEDVVRAYQV IIRLPGFLGT LEGVMDEAYR
DPLDEAYTSK LRTLSDSLVK LQEMVETTVD LDALDRHEYV IKPEFDDSLR IIRKKLDKAK
RDIDQEFNKA AHDLGQEKEK KIFLENHKVH GYCMRLTRTE AGCIRNKSGY LECSTQKNGV
YFTTRNLQNL RREFDQQSQN YNRTQASLVN EVVGVAASYC PVLEKLAAVL AHLDVIISFA
HCSVHAPIEY VRPKMHNRGE GQTVLKEARH PCLEMQDDVQ FITNDVELTK DKSSFLIITG
PNMGGKSTYI RQIGVIALMA QVGCFVPCAE AEMTIFDSIL ARVGASDSQL KGVSTFMAEM
LETANILKSA TAESLIIIDE LGRGTSTYDG FGLAWAISEH IIKEIGCSAM FATHFHELTA
LADQHAQVKN LHVTAHISGS EEGDAKREVT LLYKVEDGIC DQSFGIHVAE LVRFPDKVVR
MAKRKADELE DFTTKHEDLG LRYNKSDVEE GSAMLKDVLV RWKDEVKGGA MSKQDMVKKM
RELVASDEKL LANPFFQSVK LL
//
