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Database: UniProt
Entry: A0A0G8B0A9_9SYNE
LinkDB: A0A0G8B0A9_9SYNE
Original site: A0A0G8B0A9_9SYNE 
ID   A0A0G8B0A9_9SYNE        Unreviewed;       479 AA.
AC   A0A0G8B0A9;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=TH68_03700 {ECO:0000313|EMBL:KKZ14841.1};
OS   Candidatus Synechococcus spongiarum 142.
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=1608213 {ECO:0000313|EMBL:KKZ14841.1, ECO:0000313|Proteomes:UP000035054};
RN   [1] {ECO:0000313|EMBL:KKZ14841.1, ECO:0000313|Proteomes:UP000035054}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=142 {ECO:0000313|EMBL:KKZ14841.1};
RA   Burgsdorf I., Slaby B.M., Handley K.M., Haber M., Blom J.,
RA   Marshall C.W., Gilbert J.A., Hentschel U., Steindler L.;
RT   "Lifestyle Evolution in Cyanobacterial Symbionts of Sponges.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKZ14841.1}.
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DR   EMBL; JXUO01000120; KKZ14841.1; -; Genomic_DNA.
DR   PATRIC; fig|1608213.3.peg.592; -.
DR   Proteomes; UP000035054; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035054};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035054}.
FT   DOMAIN      173    307       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      382    451       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     181    188       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   479 AA;  53573 MW;  82F990A322A3DD8D CRC64;
     MDKNKSGAEL WRDVCHELQK NLSKPSYATW INPVGGARFD GKCLELFAHN PFAANWLRKN
     YQDLIRQLAS GIAEQPVQVR INDAPPSNQP ASKDSVSDTP SPDLPSPDPP NADSLKADPA
     HQAVAVSSPT SCRHLINGRG LNPHYLFSRF VVGGNSHMAH AACMAVARST SERFNPLFLF
     GNVGLGKTHL MQAIGHQRLQ VKPKDRVVYV TTEQFTNELI TAIRKDRTQS FREDYRQADL
     VLVDDIQFLQ GKEYTQEEFF HTFNWLHESG RQVVLASDRP PGQICDLQKR LISRFSMGLV
     ADIQSPDLET RMAILHKKAD QDKVELPEEL IYYIACNFTS NIRELEGALT RAVAYCSITS
     QPLNAKTVAP ILNMSAGSAQ VNPKRIIESV AQVFAVQAED LRGSSRKRIV SQARQMAMYL
     LRQYTSLSLS KIGQCFGRKD HATVLYAVRR ISKILDNDPE MAQQMAKVRN LLGAWKGTS
//
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