ID A0A0H2MLC4_VARPD Unreviewed; 686 AA.
AC A0A0H2MLC4;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Type IV pilus biogenesis and competence protein PilQ {ECO:0000256|ARBA:ARBA00014124};
GN Name=pilQ1 {ECO:0000313|EMBL:KLN57580.1};
GN ORFNames=VPARA_10930 {ECO:0000313|EMBL:KLN57580.1};
OS Variovorax paradoxus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=34073 {ECO:0000313|EMBL:KLN57580.1, ECO:0000313|Proteomes:UP000035170};
RN [1] {ECO:0000313|EMBL:KLN57580.1, ECO:0000313|Proteomes:UP000035170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBEA6 {ECO:0000313|EMBL:KLN57580.1,
RC ECO:0000313|Proteomes:UP000035170};
RA Poehlein A., Schuldes J., Wuebbeler J.H., Hiessl S., Steinbuechel A.,
RA Daniel R.;
RT "Genome sequence of Variovorax paradoxus TBEA6.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for type IV pilus biogenesis and competence. Could
CC function as a pore for exit of the pilus but also as a channel for
CC entry of heme and antimicrobial agents and uptake of transforming DNA.
CC {ECO:0000256|ARBA:ARBA00024678}.
CC -!- SUBUNIT: Homododecamer. Tetramer of trimer.
CC {ECO:0000256|ARBA:ARBA00025897}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|RuleBase:RU004004}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. PilQ subfamily.
CC {ECO:0000256|ARBA:ARBA00006304}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLN57580.1}.
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DR EMBL; JZWI01000006; KLN57580.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H2MLC4; -.
DR PATRIC; fig|34073.19.peg.1110; -.
DR Proteomes; UP000035170; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 2.60.40.3470; -; 1.
DR Gene3D; 2.60.40.3500; -; 1.
DR Gene3D; 3.30.1370.120; -; 1.
DR Gene3D; 3.30.1370.130; -; 1.
DR InterPro; IPR021731; AMIN_dom.
DR InterPro; IPR001775; GspD/PilQ.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR013355; Pilus_4_PilQ.
DR InterPro; IPR011662; Secretin/TonB_short_N.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR NCBIfam; TIGR02515; IV_pilus_PilQ; 1.
DR PANTHER; PTHR30604:SF1; DNA UTILIZATION PROTEIN HOFQ; 1.
DR PANTHER; PTHR30604; PROTEIN TRANSPORT PROTEIN HOFQ; 1.
DR Pfam; PF11741; AMIN; 2.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR PRINTS; PR00811; BCTERIALGSPD.
DR SMART; SM00965; STN; 1.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Competence {ECO:0000256|ARBA:ARBA00023287};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000035170};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU004004}.
FT DOMAIN 273..321
FT /note="Secretin/TonB short N-terminal"
FT /evidence="ECO:0000259|SMART:SM00965"
SQ SEQUENCE 686 AA; 73263 MW; B44BE04CF348D49E CRC64;
MAHAQNAIEA VTSSTQSGAE VIRIDLAQPL AALPTGFAVQ TPARIALDFP GVTNAIGRSA
IEVNQGNLRS VNVVQAGERS RVVLNLKQAT AYKTEIQGKS LLVILEPVAG TALASSTPTV
FAENRNRDTL PLRDVDFRLG ADNTGRVIVD LPNNQVGVDV RQQGKNLVVE FTKSTLPEGL
RRRLDVADFN TPVQLITSQQ SGDRVRMTIE AKGDWEHSAY QSENQFVVEL RARKVDPAKL
TQGVGYNGEK LSLNFQNIEI RSLLQVIADF TNFNIVTSDS VTGALTLRLK DVPWDQALDI
IMQAKNLGMR KNGSVLWIAP KDEINAKEKL EFEAKAAIEN LEPVRTQSFQ LNYTKAIAIA
QGLTGTGASA GGGGGSGTTT RILSPRGSVI AESRTNQLFV SDIPSRLAQV ADLIQKLDIP
VRQVLIEARI VEASDTFGKS LGVRLGGGIA GERIASSSGN RAFGTVGVMP VTGTGTTGPT
TTWTNSNFIN LPAGDAGGTG NAAGTFAISL FNSSFSRMLN LEISALEADG KGKLVSSPRV
ITADQTKALI EQGEEIPYQQ ATSSGATSIS FRKAVLKLEV TPQITPEGNI ILTLDVSKDA
RGVNTSAGPA INTKHVQTEV LVENGGTVVI GGIFELTETN DESRVPVLGE VPYLGALFRK
RERVANKTEM LVFITPKMIT DRNAAR
//
