ID A0A0H2MLV6_VARPD Unreviewed; 337 AA.
AC A0A0H2MLV6;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=2-oxoisovalerate dehydrogenase subunit beta {ECO:0000313|EMBL:KLN57760.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:KLN57760.1};
GN Name=bkdA2 {ECO:0000313|EMBL:KLN57760.1};
GN ORFNames=VPARA_12730 {ECO:0000313|EMBL:KLN57760.1};
OS Variovorax paradoxus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=34073 {ECO:0000313|EMBL:KLN57760.1, ECO:0000313|Proteomes:UP000035170};
RN [1] {ECO:0000313|EMBL:KLN57760.1, ECO:0000313|Proteomes:UP000035170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBEA6 {ECO:0000313|EMBL:KLN57760.1,
RC ECO:0000313|Proteomes:UP000035170};
RA Poehlein A., Schuldes J., Wuebbeler J.H., Hiessl S., Steinbuechel A.,
RA Daniel R.;
RT "Genome sequence of Variovorax paradoxus TBEA6.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLN57760.1}.
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DR EMBL; JZWI01000006; KLN57760.1; -; Genomic_DNA.
DR RefSeq; WP_047783794.1; NZ_JZWI01000006.1.
DR AlphaFoldDB; A0A0H2MLV6; -.
DR PATRIC; fig|34073.19.peg.1295; -.
DR Proteomes; UP000035170; Unassembled WGS sequence.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:KLN57760.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000035170}.
FT DOMAIN 4..179
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 337 AA; 36886 MW; C456064131076946 CRC64;
MASMTMIQAL RSAMDVMLER DDNVIIYGQD VGYFGGVFRC TEGLQAKYGR SRVFDAPINE
GGIVGSAIGM GAYGLRPVVE VQFADYVYPA YDQIVSEAAR LRYRSAGDFT APITIRMPCG
GGIYGGQTHS QSPEALFTHV CGLRTVMPSN PRDAKGLLIA SIENDDPVIF LEPKRLYNGP
FDGHHDRPLV SWSGHPLGEV PEGYYTVPLE SATVFRPGAD LTVISYGTMV FVSEAAAQET
GIDAEIIDLR SLWPLDLETL VASVKKTGRC VIVHEATRTN GFGAELTALV QEHCFHYLEA
PIQRVAGWDT PYPHAQEWAY FPGPARVGAA FRRAMEN
//
