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Database: UniProt
Entry: A0A0H2UHF2_RAT
LinkDB: A0A0H2UHF2_RAT
Original site: A0A0H2UHF2_RAT 
ID   A0A0H2UHF2_RAT          Unreviewed;      1093 AA.
AC   A0A0H2UHF2;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 7 {ECO:0000313|Ensembl:ENSRNOP00000009920};
GN   Name=Kcnh7 {ECO:0000313|Ensembl:ENSRNOP00000009920,
GN   ECO:0000313|RGD:621112};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000009920, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000009920, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009920,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000009920}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009920};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000009920}.
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DR   EMBL; AABR07052349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07052350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07052351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07052352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSRNOT00000009920; ENSRNOP00000009920; ENSRNOG00000007528.
DR   RGD; 621112; Kcnh7.
DR   GeneTree; ENSGT00900000140833; -.
DR   OMA; QMTTDIQ; -.
DR   Reactome; R-RNO-1296072; Voltage gated Potassium channels.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000007528; -.
DR   ExpressionAtlas; A0A0H2UHF2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01470; ERGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    310    331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    447    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    512    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    543    564       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      643    743       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      925    952       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1093 AA;  123275 MW;  406DF4946F7F15D3 CRC64;
     GSTFICNTHI IPVKNQEGVA MMFIINFEYV TDEDNAASPE RVNPILPVKS VNRKLFGFKF
     PGLRVLTYRK QSLPQEDPDV VVIDSSKHSD DSVAMKHFKS PTKESCSPSE ADDTKALIQP
     SQCSPLVNIS GPLDHSSPKR QWDRLYPDML QSSSQLTHSR SRESLCSIRR ASSVHDIEGF
     NVHPKNIFRD RHASEDNGRN VKGPFNHIKS SLLGSTSDSN LNKYSTINKI PQLTLNFSDV
     KTEKKNTSPP SSDKTIIAPK VKERTHNVTE KVTQVLSLGA DVLPEYKLQT PRINKFTILH
     YSPFKAVWDW LILLLVIYTA IFTPYSAAFL LNDREEQKRR ECGYSCSPLN VVDLIVDIMF
     IIDILINFRT TYVNQNEEVV SDPAKIAVHY FKGWFLIDMV AAIPFDLLIF GSGSDETTTL
     IGLLKTARLL RLVRVARKLD RYSEYGAAVL MLLMCIFALI AHWLACIWYA IGNVERPYLT
     DKIGWLDSLG TQIGKRYNDS DSSSGPSIKD KYVTALYFTF SSLTSVGFGN VSPNTNSEKI
     FSICVMLIGS LMYASIFGNV SAIIQRLYSG TARYHMQMLR VKEFIRFHQI PNPLRQRLEE
     YFQHAWTYTN GIDMNMVLKG FPECLQADIC LHLNQTLLQN CKAFRGASKG CLRALAMKFK
     TTHAPPGDTL VHCGDVLTAL YFLSRGSIEI LKDDIVVAIL GKNDIFGEMV HLYAKPGKSN
     ADVRALTYCD LHKIQREDLL EVLDMYPEFS DHFLTNLELT FNLRHESAKS QSINDSEGDT
     CKLRRRRLSF ESEGDKDFSK ENSANDADDS TDTIRRYQSS KKHFEEKKSR SSSFISSIDD
     EQKPLFLGTV DSTPRMVKAS RHHGEEAAPP SGRIHTDKRS HSCKDITDTH SWEREHARAQ
     PEECSPSGLQ RAAWGISETE SDLTYGEVEQ RLDLLQEQLN RLESQMTTDI QAILQLLQKQ
     TTVVPPAYSM VTAGAEYQRP ILRLLRTSHP RASIKTDRSF SPSSQCPEFL DLEKSKLKSK
     ESLSSGKRLN TASEDNLTSL LKQDSDASSE LDPRQRKSYL HPIRHPSLPD SSLSTVGILG
     LHRHVSDPGL PGK
//
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