ID A0A0H3J2L8_CLOPA Unreviewed; 305 AA.
AC A0A0H3J2L8;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Hydroxypyruvate reductase {ECO:0000313|EMBL:AJA50141.1};
DE EC=1.1.1.81 {ECO:0000313|EMBL:AJA50141.1};
DE SubName: Full=Phosphoglycerate dehydrogenase {ECO:0000313|EMBL:KRU13846.1};
DE EC=1.1.1.95 {ECO:0000313|EMBL:KRU13846.1};
GN ORFNames=CLPA_c00180 {ECO:0000313|EMBL:AJA50141.1}, CP6013_03101
GN {ECO:0000313|EMBL:KRU13846.1};
OS Clostridium pasteurianum DSM 525 = ATCC 6013.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262449 {ECO:0000313|EMBL:AJA50141.1, ECO:0000313|Proteomes:UP000030905};
RN [1] {ECO:0000313|EMBL:AJA50141.1, ECO:0000313|Proteomes:UP000030905}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 525 {ECO:0000313|EMBL:AJA50141.1}, and DSM 525 / ATCC 6013
RC {ECO:0000313|Proteomes:UP000030905};
RX PubMed=25700415;
RA Poehlein A., Grosse-Honebrink A., Zhang Y., Minton N.P., Daniel R.;
RT "Complete Genome Sequence of the Nitrogen-Fixing and Solvent-Producing
RT Clostridium pasteurianum DSM 525.";
RL Genome Announc. 3:e01591-e01514(2015).
RN [2] {ECO:0000313|EMBL:KRU13846.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 6013 {ECO:0000313|EMBL:KRU13846.1};
RA Pyne M.E., Utturkar S.M., Brown S.D., Moo-Young M., Chung D.A., Chou P.C.;
RT "Improved Draft Genome Sequence of Clostridium pasteurianum Strain ATCC
RT 6013 (DSM 525) Using a Hybrid Next-Generation Sequencing Approach.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KRU13846.1, ECO:0000313|Proteomes:UP000028042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6013 {ECO:0000313|EMBL:KRU13846.1,
RC ECO:0000313|Proteomes:UP000028042};
RX PubMed=25103768;
RA Pyne M.E., Utturkar S., Brown S.D., Moo-Young M., Chung D.A., Chou C.P.;
RT "Improved Draft Genome Sequence of Clostridium pasteurianum Strain ATCC
RT 6013 (DSM 525) Using a Hybrid Next-Generation Sequencing Approach.";
RL Genome Announc. 2:0-0(0).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP009268; AJA50141.1; -; Genomic_DNA.
DR EMBL; JPGY02000001; KRU13846.1; -; Genomic_DNA.
DR RefSeq; WP_004455608.1; NZ_JPGY02000001.1.
DR AlphaFoldDB; A0A0H3J2L8; -.
DR GeneID; 76624531; -.
DR KEGG; cpae:CPAST_c00180; -.
DR KEGG; cpat:CLPA_c00180; -.
DR PATRIC; fig|1262449.3.peg.3755; -.
DR eggNOG; COG0111; Bacteria.
DR Proteomes; UP000028042; Unassembled WGS sequence.
DR Proteomes; UP000030905; Chromosome.
DR GO; GO:0016618; F:hydroxypyruvate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd05303; PGDH_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719,
KW ECO:0000313|EMBL:AJA50141.1}; Pyruvate {ECO:0000313|EMBL:AJA50141.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030905}.
FT DOMAIN 8..304
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 108..279
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 305 AA; 33593 MW; 9A20ADDA67689D26 CRC64;
MLRILANDGM EKKTIEILEK KGFEVLSGHL DGDDLLKEVK NIDCLIVRSA TKVRKDLIDI
AASTGRLKLI IRGGVGIDNI DAAYAIEKGI QVNNTPNASS ISVAEMTFGH MLSVSRKIYL
SNVTMREGKW EKKKYQGTEL YGRTLGLIGF GRIAREVAKR AVAFGMKVMY YDICTAENTG
ECICATKDGI LRESDFISLH IPYKKGEPYV IGEKEFQIIK KGAYIINCAR GGVIDENALV
KALDEGKIAG AALDVFEKEP PANELIIKNP KISLTPHIGA ATVEAQERIG DEIVNIIDKF
FNNKN
//
