ID A0A0H3J8T8_CLOPA Unreviewed; 595 AA.
AC A0A0H3J8T8;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:KRU14349.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:KRU14349.1};
DE SubName: Full=Stage V sporulation protein D {ECO:0000313|EMBL:AJA53625.1};
GN Name=spoVD2 {ECO:0000313|EMBL:AJA53625.1};
GN ORFNames=CLPA_c35810 {ECO:0000313|EMBL:AJA53625.1}, CP6013_03607
GN {ECO:0000313|EMBL:KRU14349.1};
OS Clostridium pasteurianum DSM 525 = ATCC 6013.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262449 {ECO:0000313|EMBL:AJA53625.1, ECO:0000313|Proteomes:UP000030905};
RN [1] {ECO:0000313|EMBL:AJA53625.1, ECO:0000313|Proteomes:UP000030905}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 525 {ECO:0000313|EMBL:AJA53625.1}, and DSM 525 / ATCC 6013
RC {ECO:0000313|Proteomes:UP000030905};
RX PubMed=25700415;
RA Poehlein A., Grosse-Honebrink A., Zhang Y., Minton N.P., Daniel R.;
RT "Complete Genome Sequence of the Nitrogen-Fixing and Solvent-Producing
RT Clostridium pasteurianum DSM 525.";
RL Genome Announc. 3:e01591-e01514(2015).
RN [2] {ECO:0000313|EMBL:KRU14349.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 6013 {ECO:0000313|EMBL:KRU14349.1};
RA Pyne M.E., Utturkar S.M., Brown S.D., Moo-Young M., Chung D.A., Chou P.C.;
RT "Improved Draft Genome Sequence of Clostridium pasteurianum Strain ATCC
RT 6013 (DSM 525) Using a Hybrid Next-Generation Sequencing Approach.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KRU14349.1, ECO:0000313|Proteomes:UP000028042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6013 {ECO:0000313|EMBL:KRU14349.1,
RC ECO:0000313|Proteomes:UP000028042};
RX PubMed=25103768;
RA Pyne M.E., Utturkar S., Brown S.D., Moo-Young M., Chung D.A., Chou C.P.;
RT "Improved Draft Genome Sequence of Clostridium pasteurianum Strain ATCC
RT 6013 (DSM 525) Using a Hybrid Next-Generation Sequencing Approach.";
RL Genome Announc. 2:0-0(0).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP009268; AJA53625.1; -; Genomic_DNA.
DR EMBL; JPGY02000001; KRU14349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H3J8T8; -.
DR KEGG; cpae:CPAST_c35810; -.
DR KEGG; cpat:CLPA_c35810; -.
DR PATRIC; fig|1262449.3.peg.2480; -.
DR eggNOG; COG0768; Bacteria.
DR Proteomes; UP000028042; Unassembled WGS sequence.
DR Proteomes; UP000030905; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:KRU14349.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030905};
KW Transferase {ECO:0000313|EMBL:KRU14349.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..220
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 265..585
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 595 AA; 65551 MW; 8F627C0C1C5375F1 CRC64;
MSILKYKKNS TKMFTNKRLL GVFMIFGLVF VLVIGRLFYL MVSNSKVYKT KALQQWTSQI
SIPAKRGRIL DRNNNELAVS VEAYRIDIDM NTLRQSLKSK SITMDQLANK LSIILSKSSK
EISDILYLKS PNGMPVKFAT LARKIDKAQA DKIKELKISG FIVSSDSKRV YKNNNFLAST
LGYTNSEDSG VSGVELSYNK ELSGIPGQKI LETDNVGNQL PYEDSQYIAP VDGKDLVLTI
DQTIQLYAEQ AAEKALTANK AKSVTITVMN PKNGEILAMV NKPDYNPNDP NGAKNKTGEE
IAASWKNNAV QNTFEPGSIF KVITSYAAIS ENVVNDETRF PDPGYVMVDG YPINEWNLTG
FPDQTFQDII KNSSNVGFVK LGVDLLGKDK LFKYINLFGF GQRTGVDLPG ESKGIVRSID
KTNKFDLATI SFGQGISVTA MQYLAAFNAV ANGGTWITPH VMKEFVHVDS NTNKQVLDTT
YNNFNKKEIL DPNMSSTLRT YLRKVVTDGV GKAAEVPGLD IAGKTGTAQK SSTKGGYAPG
KYMSSFAGMS PANDPKITML ISIDEPDSNN YYAGQTAAPV AKELFQEIFD YMNSK
//
