GenomeNet

Database: UniProt
Entry: A0A0H4LE61_9LACO
LinkDB: A0A0H4LE61_9LACO
Original site: A0A0H4LE61_9LACO 
ID   A0A0H4LE61_9LACO        Unreviewed;       194 AA.
AC   A0A0H4LE61;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase {ECO:0000256|ARBA:ARBA00014944};
DE            EC=2.7.8.5 {ECO:0000256|ARBA:ARBA00013170};
DE   AltName: Full=Phosphatidylglycerophosphate synthase {ECO:0000256|ARBA:ARBA00033018};
GN   Name=pgsA {ECO:0000313|EMBL:HJF85860.1};
GN   ORFNames=C5L30_002413 {ECO:0000313|EMBL:TDG71833.1}, K8V88_00315
GN   {ECO:0000313|EMBL:HJF85860.1};
OS   Companilactobacillus farciminis.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Companilactobacillus.
OX   NCBI_TaxID=1612 {ECO:0000313|EMBL:HJF85860.1, ECO:0000313|Proteomes:UP000747013};
RN   [1] {ECO:0000313|EMBL:TDG71833.1, ECO:0000313|Proteomes:UP000295257}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29644 {ECO:0000313|EMBL:TDG71833.1,
RC   ECO:0000313|Proteomes:UP000295257};
RX   PubMed=30830251; DOI=.1007/s00253-019-09701-6;
RA   Buron-Moles G., Chailyan A., Dolejs I., Forster J., Miks M.H.;
RT   "Uncovering carbohydrate metabolism through a genotype-phenotype
RT   association study of 56 lactic acid bacteria genomes.";
RL   Appl. Microbiol. Biotechnol. 103:3135-3152(2019).
RN   [2] {ECO:0000313|EMBL:TDG71833.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 29644 {ECO:0000313|EMBL:TDG71833.1};
RA   Buron G., Chaylann A., Dolejs I., Forster J., Miks M.H.;
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:HJF85860.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=7886 {ECO:0000313|EMBL:HJF85860.1};
RX   PubMed=33868800;
RA   Gilroy R., Ravi A., Getino M., Pursley I., Horton D.L., Alikhan N.F.,
RA   Baker D., Gharbi K., Hall N., Watson M., Adriaenssens E.M.,
RA   Foster-Nyarko E., Jarju S., Secka A., Antonio M., Oren A., Chaudhuri R.R.,
RA   La Ragione R., Hildebrand F., Pallen M.J.;
RT   "Extensive microbial diversity within the chicken gut microbiome revealed
RT   by metagenomics and culture.";
RL   PeerJ 9:0-0(2021).
RN   [4] {ECO:0000313|EMBL:HJF85860.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=7886 {ECO:0000313|EMBL:HJF85860.1};
RA   Gilroy R.;
RL   Submitted (SEP-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein catalyzes the committed step to the synthesis of
CC       the acidic phospholipids. {ECO:0000256|ARBA:ARBA00003973}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-
CC         diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP +
CC         H(+); Xref=Rhea:RHEA:12593, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:60110, ChEBI:CHEBI:60377; EC=2.7.8.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001566};
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis;
CC       phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00005042}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000256|ARBA:ARBA00010441, ECO:0000256|RuleBase:RU003750}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:HJF85860.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DYWC01000010; HJF85860.1; -; Genomic_DNA.
DR   EMBL; PUFN01000019; TDG71833.1; -; Genomic_DNA.
DR   RefSeq; WP_010020559.1; NZ_PUFN01000019.1.
DR   STRING; 1612.ABB44_07355; -.
DR   OrthoDB; 9796672at2; -.
DR   UniPathway; UPA00084; UER00503.
DR   Proteomes; UP000295257; Unassembled WGS sequence.
DR   Proteomes; UP000747013; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008444; F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006655; P:phosphatidylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   InterPro; IPR048254; CDP_ALCOHOL_P_TRANSF_CS.
DR   InterPro; IPR004570; Phosphatidylglycerol_P_synth.
DR   NCBIfam; TIGR00560; pgsA; 1.
DR   PANTHER; PTHR14269:SF62; CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE 1, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR14269; CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   PIRSF; PIRSF000847; Phos_ph_gly_syn; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000295257};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003750};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        43..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        168..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   194 AA;  21637 MW;  CC72DACFE9C6275A CRC64;
     MVWNVPNKLT MLRIILIPVF IILLAFNWSG LGDIYVANDL IPVNHVLATV VFIVASLTDL
     LDGKIARKYH LVSNFGKFAD TLADKMLVMT AFIFLVSFKM APAWVVAIIV CRELAVTGLR
     TIVLEVGGKV MAAQMPGKIK TTTQMLAIIF LLMHNIFFSA INIPIGEIFL YICLIFTIYS
     GADYFIQSKD IFKS
//
DBGET integrated database retrieval system