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Database: UniProt
Entry: A0A0H4R3U8_9LACO
LinkDB: A0A0H4R3U8_9LACO
Original site: A0A0H4R3U8_9LACO 
ID   A0A0H4R3U8_9LACO        Unreviewed;       438 AA.
AC   A0A0H4R3U8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   05-JUL-2017, entry version 17.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ABM34_08990 {ECO:0000313|EMBL:AKP68450.1};
OS   Lactobacillus ginsenosidimutans.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1007676 {ECO:0000313|EMBL:AKP68450.1, ECO:0000313|Proteomes:UP000036106};
RN   [1] {ECO:0000313|Proteomes:UP000036106}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EMML 3041 {ECO:0000313|Proteomes:UP000036106};
RA   Kim M.K., Im W.-T., Srinivasan S., Lee J.-J.;
RT   "Lactobacillus ginsenosidimutans/EMML 3141/ whole genome sequencing.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP012034; AKP68450.1; -; Genomic_DNA.
DR   EnsemblBacteria; AKP68450; AKP68450; ABM34_08990.
DR   KEGG; lgn:ABM34_08990; -.
DR   PATRIC; fig|1007676.4.peg.1819; -.
DR   KO; K02313; -.
DR   Proteomes; UP000036106; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000036106};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036106}.
FT   DOMAIN      134    265       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      346    415       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     142    149       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   438 AA;  49258 MW;  934FE53C2DF4B476 CRC64;
     MKKEITSTSY STWVESAKPL YIDGNDIHIS VQSELHKDYW ERNYVKNIAI DSYQYNGTEL
     NPIIETEEDR KESENSSEPA PQNDSDSNNT DSSSHLFENT HLNPKYTFDT FIVGGANNMA
     HAAAVAAAGE PGQIYNPLFI YGGVGLGKTH LMQAIGHEML KNNPKARVKY VTSETFTNDL
     VVSIGSGSQD AFREEYRSCD LLLIDDVQFF ADKRGTQEEF FHTFNRLHEN NKQIVLTSDR
     LPNEIPKLQE RLVSRFKWGL SVDITAPDLE TRIAILRNKA KAEHLEIPND TLSYIAEQIS
     TNVRELEGAL LRVQAYSTMR NADINKALAA DALKALKLSK AKGGLTVTTI QNKVAKYYHV
     SIADLKGKKR VKTIVLPRQI AMYLSRELTD RSLPQIGMEF GGKDHTTVMH SCDKIGELTA
     KNDDVKQAVE ELRDELKN
//
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