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Database: UniProt
Entry: A0A0H4UWJ5_9COXI
LinkDB: A0A0H4UWJ5_9COXI
Original site: A0A0H4UWJ5_9COXI 
ID   A0A0H4UWJ5_9COXI        Unreviewed;       449 AA.
AC   A0A0H4UWJ5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AKQ33130.1};
GN   ORFNames=CleRT_00010 {ECO:0000313|EMBL:AKQ33130.1};
OS   Coxiella-like endosymbiont.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Coxiellaceae.
OX   NCBI_TaxID=1592897 {ECO:0000313|EMBL:AKQ33130.1, ECO:0000313|Proteomes:UP000063965};
RN   [1] {ECO:0000313|EMBL:AKQ33130.1, ECO:0000313|Proteomes:UP000063965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CRt {ECO:0000313|EMBL:AKQ33130.1,
RC   ECO:0000313|Proteomes:UP000063965};
RX   PubMed=26025560; DOI=10.1093/gbe/evv108;
RA   Gottlieb Y., Lalzar I., Klasson L.;
RT   "Distinctive Genome Reduction Rates Revealed by Genomic Analyses of
RT   Two Coxiella-Like Endosymbionts in Ticks.";
RL   Genome Biol. Evol. 7:1779-1796(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP011126; AKQ33130.1; -; Genomic_DNA.
DR   RefSeq; WP_048874730.1; NZ_CP011126.1.
DR   EnsemblBacteria; AKQ33130; AKQ33130; CleRT_00010.
DR   KEGG; cey:CleRT_00010; -.
DR   PATRIC; fig|1592897.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000063965; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000063965};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000063965}.
FT   DOMAIN      357    426       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     154    161       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   449 AA;  51073 MW;  20D112E7E0467BAB CRC64;
     MSVPTSLWDK CLNYLRDEIP PQQYNTWIRP LHAVESKQNG LLLLAPNRFV LDWINEQFLT
     RIRELLDELT ETPPKIELQI GNKSSTEADP KNGINTPIHK TIVGTPLVHS HTNINSNFTF
     ETFVEGKSNQ LARAAATQVA ENPGQAYNPL FTYGGVGLGK THLMHAVGNA ILQKNPEIKV
     LYLHSERFVA DMIKALQHNA MNDFKRFYRS VNALLIDDIQ FFAGKDRSQE EFFHTFNALL
     DGQQQIILTC DRYPKEINGL EERLQSRFGW GLTVAIEPPE LETRVAILMT KAEQLKMHLP
     HEVAFFIAKH IQSNVRELEG ALKRVIANAH FTGQPITVEF TRDALKDLLT LQARLITIEN
     IQRIVAEYYK IKVADLLAKR RSRSIARPRQ MAMALAKELT NHSLPEIGDS FGGRDHTTVL
     HACRKVRELL ATSLDILEDY KNLMRILSG
//
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