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Database: UniProt
Entry: A0A0H5S154_BRUMA
LinkDB: A0A0H5S154_BRUMA
Original site: A0A0H5S154_BRUMA 
ID   A0A0H5S154_BRUMA        Unreviewed;       883 AA.
AC   A0A0H5S154;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   20-DEC-2017, entry version 8.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=bma-vha-5 {ECO:0000313|WormBase:Bm3851};
GN   Synonyms=Bma-vha-5 {ECO:0000313|EMBL:CRZ22452.1};
GN   ORFNames=Bm3851 {ECO:0000313|WormBase:Bm3851}, BM_Bm3851
GN   {ECO:0000313|EMBL:CRZ22452.1};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ22452.1};
RN   [1] {ECO:0000313|EMBL:CRZ22452.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CRZ22452.1};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|EMBL:CRZ22452.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CRZ22452.1};
RA   Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA   Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; LN856451; CRZ22452.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Bm3851; Bm3851; WBGene00224112.
DR   WormBase; Bm3851; BM41647; WBGene00224112; Bma-vha-5.
DR   OMA; CYLSQWY; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0044298; C:cell body membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0070382; C:exocytic vesicle; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005771; C:multivesicular body; IEA:EnsemblMetazoa.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0040002; P:collagen and cuticulin-based cuticle development; IEA:EnsemblMetazoa.
DR   GO; GO:1990182; P:exosomal secretion; IEA:EnsemblMetazoa.
DR   GO; GO:0050891; P:multicellular organismal water homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0051046; P:regulation of secretion; IEA:EnsemblMetazoa.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    451    469       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    570       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    582    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    613    636       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    678    697       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    823    847       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       58     78       {ECO:0000256|SAM:Coils}.
FT   COILED       97    124       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   883 AA;  102112 MW;  FCA7E050162A52E8 CRC64;
     MGSLYRSEQM RFCQMIVQKD AAFSCVAELG KHPYVQFKDL NANVNPFQKM YLRDIQRFEE
     LERKLRFLDA QIRKDDIEVN DDVGGDDTYE VLAPHELNQL EGTLIDLERD VINMNENNII
     LKRNYFELKE WEAILEKTDH FFEEGISDVA MHEIEAMQED SALVLRSGKE PIGFLAGVVN
     RDRVNAFEKV LWRACHKTAF IRTTDIEEEL ENPDSGEICS KSVFLIFYKG DRLRIIIEKV
     CEGFKAKLYN NCPKNSKDRH AAARDVKARI SDMRTVLGQT QEHRYKVLQA ASNSVRQWQK
     EVRMQKSVYY TLNLFTFDAI GKFFVAECWV PYVDLENVRL ALEEGVRKSG SSVRPVLNLL
     ETTEEPPTYN RVNKFTRVFQ AIVDSYGTAS YLEINPAPYT IITFPFIFSC MFGDLGHGII
     MLLVGLWMVL REKNLAARNI KDEIFNMFYG GRYIILLMGI FSIYAGFLYN DLFAKSFNLF
     GSKWRNPFPN AEIESWDSQS ILMHKEIMID LPPSRSYMHD SGPYWFGVDP VWNLAENRLN
     FSNSLKMKLS VILGIAQMTF GVFLSLLNYI YFKSKIEICT VFIPQILFML CIFIYLCVQI
     IIKWLFFWVQ EEYIFGLLYP GSNCAPSLLI GLINMFMFKY RRLGFLNESK IVSQNDGHVT
     YENWPDCYLS QWYPGQSTLE AILVIIAVIC VPVMLFGKPI HFLLHRKKRN VISDNAVIWM
     NQESEKAEIT LNENGSGLNK KDWEETISDN ECEEESFGDV MVHQAIHTIE YVLGCVSHTA
     SYLRLWALSL AHAQLSEVLW EMVLVQAFSI SGIAGYIAAY LVFFAFGVLT VSILVLMEGL
     SAFLHALRLH WVEFQSKFYL GLGYPFLPFY FKDVLLKANV IEK
//
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