ID A0A0H5S2F9_BRUMA Unreviewed; 638 AA.
AC A0A0H5S2F9;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Trehalase {ECO:0000256|ARBA:ARBA00019905, ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757, ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN Name=bma-tre-2 {ECO:0000313|WormBase:Bm5570};
GN Synonyms=Bma-tre-2 {ECO:0000313|EMBL:CRZ22873.1,
GN ECO:0000313|WBParaSite:Bm5570.1};
GN ORFNames=Bm5570 {ECO:0000313|WormBase:Bm5570}, BM_Bm5570
GN {ECO:0000313|EMBL:CRZ22873.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ22873.1};
RN [1] {ECO:0000313|EMBL:CRZ22873.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22873.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ22873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22873.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm5570.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|ARBA:ARBA00001576,
CC ECO:0000256|RuleBase:RU361180};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
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DR EMBL; LN856708; CRZ22873.1; -; Genomic_DNA.
DR STRING; 6279.A0A0H5S2F9; -.
DR EnsemblMetazoa; Bm5570.1; Bm5570.1; WBGene00225831.
DR WBParaSite; Bm5570.1; Bm5570.1; WBGene00225831.
DR WormBase; Bm5570; BM25183; WBGene00225831; Bma-tre-2.
DR OMA; KKIFCEG; -.
DR OrthoDB; 1329212at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR001661; Glyco_hydro_37.
DR InterPro; IPR018232; Glyco_hydro_37_CS.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR PANTHER; PTHR23403:SF1; TREHALASE; 1.
DR Pfam; PF01204; Trehalase; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR PROSITE; PS00928; TREHALASE_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361180};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
SQ SEQUENCE 638 AA; 72034 MW; F7E141372BD8DACB CRC64;
MTVIDTTAVK TTNILPVTTS ISTTTAKTSA DTEAQIINND TRDIPVSRKF GVSGPPTPIT
TGTIKTEIMK EIYCSGSLLE AVQKANIFHD CKHFVDMPLK IDAESTLHDW HELIESGQID
ENSLRHFVES HFDEPGGELD TCEPSDFDPE YGKFESINSP SYRQWAKELH RKWPTLCRKV
SDRVIADPEK FSLIPLPKPF VVPGGRFREM YYWDSFFTIK GLLASGMHDT VRGMIENMGS
LIERFGYVPN GNRVYYLNRS QPPLLTWCLS AYYEATGDKK FVFTGARWFE REFEFFQKHK
SIQLPGVTSL LYRYHVVAVG PRPESYREDV ESAHHIEDVL EKQRLWGDIA AAAESGRDFS
SRWFSQDGPV AGKMGSTRTS SILPVDLNAI ICGNLRLMAN LYEVIDDISN AEQCREQFRS
MKQAIHQVFW NEEYGCWFDY DIIHACHVNL YMDTNFFPLF SGCTHDDFDA QKIVTYMTNM
GVLAFPGGLP SSLIASGQQW DFPNAWAPTT WVVIQGLRST GQHELARQIA EKWIKRNYSM
WLVSGGRMFE KYNVASQNYN TAGGGGEYEV QEGFGWTNGV VLDLLLTYGP DLTFKSDDDK
PMTPGEGCVC CQEHQQISDG TTTTNTILVP SPADSGLQ
//
